SGER: Noninvasive Detection of Pancreatic Cancer Using Biophotonics Techniques

SGER：利用生物光子技术无创检测胰腺癌

• 批准号: 0547480
• 负责人: Vadim Backman
• 金额: $ 15.22万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547480&HistoricalAwards=false
• 关键词: SGER; Noninvasive; Detection; Pancreatic; Cancer

Backman0547480Pancreatic cancer is the fifth leading cause of cancer death in the United States with most cancers diagnosed at a late, incurable stage. None of the existing approaches, including high-resolution imaging (MRI, CT, etc.), molecular diagnostics, and endoscopic cholangiopancreatography (ERCP), has shown the capability to detect pancreatic neoplasms sufficiently early to allow effective treatment. Current imaging modalities as well as ERCP depend on the presence of a mass lesion, and, therefore, even if the resolution of these tests is improved, we will still be dealing with a tumor that is biologically too advanced for cure.The objective of this is to develop a biophotonics solution for detection of pancreatic cancerin early timepoints without the need for direct interrogation of the pancreas. Two novel complementary photonic strategies that do not suffer from the limitations of the existing approaches will be employed.

在美国，胰腺癌是癌症死亡的第五大原因，大多数癌症在晚期被诊断出来，无法治愈。现有的方法，包括高分辨率成像（MRI，CT等），分子诊断学和内窥镜胰胆管造影术（ERCP）已经显示出足够早地检测胰腺肿瘤以允许有效治疗的能力。目前的成像方式以及ERCP依赖于肿块病变的存在，因此，即使这些测试的分辨率提高，我们仍然会处理一个肿瘤，生物学上太先进的cure.The目的是开发一个生物光子解决方案，在早期时间点检测胰腺癌，而不需要直接询问胰腺。将采用两种新型互补光子策略，它们不受现有方法的限制。