SGER: Development of Minimally Invasive Optical Technique for Early Detection of Pancreatic Cancer

所提出的探索性研究的总体目标是开发一种新的高分辨率光谱成像技术，该技术利用从上皮组织以近向后方向弹性散射的光，以提取关于宏观组织组成以及细胞和亚细胞尺度的组织结构的信息。所有癌症的85%开始于上皮组织，该组织排列在身体的大部分内部器官中。尽管已经花费了很大的努力，以找到方法来识别早期胰腺癌前病变，目前可用的方法都没有显示出足够早地检测胰腺肿瘤，以允许有效treatment.Technical优点的能力：该应用程序解决了一个微创光学技术的发展，可以使早期检测胰腺原位癌变。据推测，包括其光谱，角度和偏振特性的弹性光散射的综合测量将能够检测胰腺中的癌前病变。更广泛的影响：该项目中开发的技术可能首次能够筛查胰腺癌患者，从而显着降低这种疾病的死亡率。

0417689BackmanThe overall objective of the proposed exploratory study is to develop a novel high resolution spectroscopic imaging technique that utilizes light, elastically scattered from epithelial tissues in near backward direction, to extract information about macroscopic tissue composition as well as tissue structure at the cellular and sub-cellular scale. 85% of all cancers begin in epithelial tissue, the tissue that lines most of the internal organs in the body. Despite the significant effort that has been expended to find means to identify early precancerous pancreatic lesions, none of the currently available approaches has shown the capability to detect pancreatic neoplasms sufficiently early to allow effective treatment.Technical merit: This application addresses the development of a minimally invasive optical technique that may enable early detection of pancreatic carcinogenesis in situ. It is hypothesized that comprehensive measurement of elastic light scattering including its spectral, angular, and polarization properties will enable detection of precancerous lesions in the pancreas. Broader impact: The technique developed in this project may potentially enable, for the first time, screening of patients for pancreatic cancer and, thus, significantly reduce the mortality from this disease.