CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing Applications

ID：MPS/DMR/BMAT（7623）0954919 PI：Andreescu，Emanuela ORG：克拉克森大学职业：具有生物学特性的无机纳米颗粒：制备，表征和传感应用智力优势：该职业发展计划的目标是开发和研究一类新的无机仿生材料，重点是二氧化铈基金属氧化物。该计划的目的是促进了解的机制，管理他们的生物学特性与其物理化学性质，并获得结构活性关系的合理设计的新的传感方法的基础上，这些材料的目的。 这项研究将为生物材料研究的一个新的和独特的领域提供关键的实验数据，即具有有趣的仿生性质和储氧能力的无机材料，以及它们在传感器中的应用。具体而言，这将是第一次调查的酶样活性的二氧化铈为基础的金属氧化物纳米粒子（NPs）在其物理化学和结构特征。研究将涉及：（1）通过纳米粒子表面的定制合成和系统修饰来优化和控制表面反应性，（2）确定调节纳米粒子反应性的关键参数，并使用这些特性来控制它们的生物活性，（3）测试它们的？酶样的？活性和（4）传感应用，这将利用其特殊的仿生性能，和他们的氧存储capacity. broaderimplant：这项研究介绍了一个独特的概念，在生物材料的研究竞技场，即无机材料模仿传统的生物催化剂和具有氧存储/释放能力的先进的生物医学和传感应用。从这些研究中获得的基础知识将使新一代仿生材料和设备的合理设计在稳定性，鲁棒性和低氧依赖性方面具有前所未有的性能。除了生物材料和生物传感器之外，这项研究还将影响这些材料可以找到有用应用的各种其他领域（例如，生物医学作为治疗药物来抑制活性氧，生物技术作为需要在极端条件下操作的催化剂）。该项目将对课程编制、学生培训、招聘和辅导产生重大影响。将开发一个新的上层本科生-研究生课程和基于探究的实验室模块，为克拉克森学生提供跨学科教育。 将制作用于实践实验的学习单元和教员辅助材料，通过计划的推广活动介绍给当地高中。毕业生和本科生将与教师和高中教师和学生协商，准备拟议实验的高中和普通化学版本。将实施一项提高新生保留率的试点计划。该项目将有助于化学系的努力，以加强生物分子科学计划，增加和保留科学专业的人数在克拉克森。拟议的基于探究的实验室模块将提高现代科学技术的可及性，并提供可转移到其他机构和更多学生（包括当地高中和社区大学）的材料。通过该计划，通过正在进行的计划和PI的既定合作招募的代表性不足的少数民族学生将有机会进行独立研究。

ID: MPS/DMR/BMAT(7623) 0954919 PI: Andreescu, Emanuela ORG: Clarkson UniversityTitle: CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing ApplicationsINTELLECTUAL MERIT: The objective of this career development plan is to develop and study a new class of inorganic biomimetic materials, with focus on ceria based metal oxides. The plan is designed to advance understanding of the mechanism that governs their biological properties in relation to their physicochemical properties and to derive structure-activity relations for the purpose of rational design of novel sensing approaches based on these materials. The proposed research will provide key experimental data in a new and unique area of biomaterials research, that of inorganic materials possessing interesting bio-mimetic properties and oxygen storage ability, and of their applications in sensing. Specifically, this will be the first investigation of the enzyme-like activity of ceria based metal oxides nanoparticles (NPs) in relation to their physicochemical and structural characteristics. Research will involve: (1) optimizing and controlling surface reactivity through tailored synthesis and systematic modifications of the NPs surface, (2) identifying key parameters that regulate NPs reactivity and using these properties to control their biological activity, (3) testing their ?enzyme-like? activity and (4) sensing applications that will take advantage of their special biomimetic properties, and their oxygen storage capacity.BROADER IMPACTS: This research introduces a unique concept in the biomaterials research arena, that of inorganic materials mimicking traditional biological catalysts and possessing oxygen storage/release capabilities for advanced biomedical and sensing applications. The fundamental knowledge gained from these studies will enable rational design of a new generation of bio-mimetic materials and devices with unprecedented performance in terms of stability, robustness, and low oxygen dependency. In addition to biomaterials and biosensors, this research will also impact a variety of other fields where these materials could find useful applications (e.g. biomedicine as therapeutic drugs to inactivate reactive oxygen species, biotechnology as catalysts that require operation at extreme conditions). The project will have a major impact on course development, student training, recruitment and mentoring. A new upper level undergraduate-graduate course and inquiry-based laboratory modules will be developed to provide interdisciplinary education of Clarkson students. Learning modules and instructor support materials for hands-on experiments will be created for introduction to local high schools through the planned outreach activities. Graduates and undergraduates will collaborate to prepare high school and general chemistry versions of the proposed experiments in consultation with faculty and high school teachers and students. A pilot program for enhancing retention rates of entering freshmen will be instituted. The project will contribute to the efforts of the Chemistry Department to strengthen the biomolecular science program and increase and retain the numbers of science majors at Clarkson. The proposed inquiry-based laboratory modules will enhance accessibility to modern scientific technologies and provide materials that are transferable to other institutions and to a larger number of students including local high schools and community colleges. Through this program, underrepresented minority students, recruited through on-going programs and established collaborations of the PI, will be provided with an opportunity to conduct independent research.