CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing Applications

职业：具有生物特性的无机纳米颗粒：制备、表征和传感应用

• 批准号: 0954919
• 负责人: Emanuela Andreescu
• 金额: $ 49.63万
• 依托单位: Clarkson University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0954919&HistoricalAwards=false
• 关键词: CAREER; Inorganic; Nanoparticles; Biological; Properties

ID: MPS/DMR/BMAT(7623) 0954919 PI: Andreescu, Emanuela ORG: Clarkson UniversityTitle: CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing ApplicationsINTELLECTUAL MERIT: The objective of this career development plan is to develop and study a new class of inorganic biomimetic materials, with focus on ceria based metal oxides. The plan is designed to advance understanding of the mechanism that governs their biological properties in relation to their physicochemical properties and to derive structure-activity relations for the purpose of rational design of novel sensing approaches based on these materials. The proposed research will provide key experimental data in a new and unique area of biomaterials research, that of inorganic materials possessing interesting bio-mimetic properties and oxygen storage ability, and of their applications in sensing. Specifically, this will be the first investigation of the enzyme-like activity of ceria based metal oxides nanoparticles (NPs) in relation to their physicochemical and structural characteristics. Research will involve: (1) optimizing and controlling surface reactivity through tailored synthesis and systematic modifications of the NPs surface, (2) identifying key parameters that regulate NPs reactivity and using these properties to control their biological activity, (3) testing their ?enzyme-like? activity and (4) sensing applications that will take advantage of their special biomimetic properties, and their oxygen storage capacity.BROADER IMPACTS: This research introduces a unique concept in the biomaterials research arena, that of inorganic materials mimicking traditional biological catalysts and possessing oxygen storage/release capabilities for advanced biomedical and sensing applications. The fundamental knowledge gained from these studies will enable rational design of a new generation of bio-mimetic materials and devices with unprecedented performance in terms of stability, robustness, and low oxygen dependency. In addition to biomaterials and biosensors, this research will also impact a variety of other fields where these materials could find useful applications (e.g. biomedicine as therapeutic drugs to inactivate reactive oxygen species, biotechnology as catalysts that require operation at extreme conditions). The project will have a major impact on course development, student training, recruitment and mentoring. A new upper level undergraduate-graduate course and inquiry-based laboratory modules will be developed to provide interdisciplinary education of Clarkson students. Learning modules and instructor support materials for hands-on experiments will be created for introduction to local high schools through the planned outreach activities. Graduates and undergraduates will collaborate to prepare high school and general chemistry versions of the proposed experiments in consultation with faculty and high school teachers and students. A pilot program for enhancing retention rates of entering freshmen will be instituted. The project will contribute to the efforts of the Chemistry Department to strengthen the biomolecular science program and increase and retain the numbers of science majors at Clarkson. The proposed inquiry-based laboratory modules will enhance accessibility to modern scientific technologies and provide materials that are transferable to other institutions and to a larger number of students including local high schools and community colleges. Through this program, underrepresented minority students, recruited through on-going programs and established collaborations of the PI, will be provided with an opportunity to conduct independent research.

ID：MPS/DMR/BMAT(7623)0954919 PI：Andreescu，Emanuela ORG：Clarkson University标题：Career：具有生物特性的无机纳米颗粒：制备、表征和传感应用INTELLECTUCTUAL优点：这一职业发展计划的目标是开发和研究一类新的无机仿生材料，重点是氧化铈金属氧化物。该计划的目的是促进对它们与其物理化学性质有关的生物学特性的机制的理解，并推导出结构-活性关系，以便合理设计基于这些材料的新型传感方法。这项拟议的研究将为生物材料研究的一个新的和独特的领域提供关键的实验数据，具有有趣的生物模拟特性和储氧能力的无机材料，以及它们在传感方面的应用。具体地说，这将是首次研究CeO2基金属氧化物纳米颗粒(NPs)的类酶活性与其物理化学和结构特征的关系。研究包括：(1)通过量身定制的合成和系统的修饰来优化和控制NPs表面的反应性；(2)确定调节NPs反应性的关键参数并利用这些特性来控制其生物活性；(3)测试其类似酶的性质？BROADER影响：这项研究在生物材料研究领域引入了一个独特的概念，即模仿传统生物催化剂的无机材料，并具有先进的生物医学和传感应用的储氧/释放能力。从这些研究中获得的基础知识将使新一代仿生材料和器件的合理设计具有前所未有的稳定性、健壮性和低氧依赖性。除了生物材料和生物传感器外，这项研究还将影响这些材料可以找到有用应用的其他各种领域(例如，生物医学作为治疗药物来灭活活性氧，生物技术作为催化剂需要在极端条件下操作)。该项目将对课程开发、学生培训、招聘和指导产生重大影响。将开发一门新的高级本科研究生课程和以探究为基础的实验室模块，为克拉克森学生提供跨学科教育。通过计划的外展活动，将创建用于动手实验的学习模块和教师支持材料，以便向当地高中介绍。毕业生和本科生将与教职员工和高中教师和学生协商，合作准备高中和普通化学版本的拟议实验。开展提高新生保留率的试点工作。该项目将有助于化学系加强生物分子科学计划的努力，并增加和保留克拉克森理科专业的人数。拟议的以探究为基础的实验室单元将加强获得现代科学技术的机会，并提供可转让给其他机构和包括当地高中和社区大学在内的更多学生的材料。通过这项计划，通过正在进行的计划和国际合作组织招募的人数不足的少数族裔学生将有机会进行独立研究。