Oxidative Enamine Catalysis in Organic Synthesis

有机合成中的氧化烯胺催化

• 批准号: 1057569
• 负责人: Wei Wang
• 金额: $ 45.5万
• 依托单位: University of New Mexico
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057569&HistoricalAwards=false
• 关键词: Oxidative; Enamine; Catalysis; Organic; Synthesis

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Wei Wang of the Department of Chemistry and Chemical Biology at University of New Mexico will explore new strategies termed "oxidative enamine catalysis" for the formation of C-C and C=C bonds. The synthetic strategy can be explored for a number of new cascade reactions to generate structurally diverse and biologically interesting building blocks and molecular architectures. Successfully accomplishing the project will provide powerful synthetic tools for the practice of organic synthesis and molecule constructions, which are particularly useful in the fields of pharmaceutical, chemical, agricultural industry, and biological sciences. The research has a broader impact on chemical synthesis by enabling the facile and atom-economic synthesis of versatile building blocks from simple and readily available chemicals under mild reaction conditions. Furthermore, "one-pot" cascade ways to make complex molecular architectures will address the important challenges in modern organic synthesis that are the improvement of synthetic efficiency, the use of sustainable and inexpensive chemicals, the avoidance of toxic agents, and the reduction of waste and hazardous byproducts. Finally, the broader impacts are also demonstrated in training historically underrepresented undergraduate students, by incorporating research results and experiments into undergraduate teaching labs, and by involving graduate students.

在化学部化学综合计划资助的该项目中，新墨西哥大学化学与化学生物学系的Wei Wang教授将探讨为C-C和C = C债券形成的“氧化磁胺催化”的新策略。 可以探索许多新的级联反应的合成策略，以生成结构上多样化和生物学上有趣的构件和分子体系结构。 成功完成该项目将为有机合成和分子结构实践提供强大的合成工具，这些工具在药物，化学，农业产业和生物科学领域特别有用。 这项研究通过在轻度反应条件下从简单且易于使用的化学物质中启用多功能构建块的便利和原子经济合成，对化学合成具有更广泛的影响。 此外，制造复杂分子体系结构的“一锅”级联方法将解决现代有机综合中的重要挑战，这些挑战是合成效率的提高，可持续和廉价化学物质的使用，避免有毒药物的使用以及浪费和危害副产品的减少。 最后，通过将研究成果和实验纳入本科教学实验室以及参与研究生的培训，在历史上培训的本科生中，还可以证明更广泛的影响。