Integration of Hypoxic Signaling Networks
缺氧信号网络的整合
基本信息
- 批准号:1121380
- 负责人:
- 金额:$ 60万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-15 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Oxygen is needed for the production of sufficient cellular energy to sustain life. Low oxygen availability, or anoxia, therefore has devastating effects on the viability of many organisms, including plants. Reduction in oxygen levels can come from the plant's own consumption of the available oxygen in densely packed tissues, or from the vagaries of the surroundings such as soil compaction, seasonal flooding and even agricultural practices related to cultivation or irrigation. Surviving these conditions requires the plant to sense the lowering of oxygen availability and shift its energy metabolism to systems to cope with the impending energy deficit. Although this response is essential for survival, our current understanding of this sensory system in plants is highly incomplete, especially at the level of the cellular events that sense and signal a fall in oxygen availability. Therefore, the research in this proposal seeks to more fully characterize the early events that trigger, coordinate and regulate plant responses to low oxygen availability using an integrated approach of imaging of low oxygen-related cellular signaling activities, characterization of associated changes in gene expression and analysis of the responses of mutants impaired in these cell and molecular events. In addition to advancing fundamental knowledge of how plants adapt to the environment, the research in this proposal will also be of long-term relevance to agriculture where seasonal flooding, likely exacerbated by climate change, may become a significant factor in future crop productivity. Integrated into this basic research is also an effort to develop a plant biology movie resource aimed at engaging and educating the general public. This effort will intimately involve undergraduate students in the making and presentation of the movies.
氧气是产生维持生命所需的足够的细胞能量所必需的。因此,低氧可用性或缺氧对许多生物体(包括植物)的生存能力具有破坏性影响。氧气水平的降低可能来自植物自身对密集组织中可用氧气的消耗,或者来自环境的变幻莫测,如土壤压实,季节性洪水,甚至与耕作或灌溉有关的农业实践。在这些条件下生存需要植物感觉到氧气供应的降低,并将其能量代谢转移到系统中,以科普即将到来的能量不足。虽然这种反应对于生存至关重要,但我们目前对植物中这种感觉系统的理解非常不完整,特别是在感知和发出氧气可用性下降信号的细胞事件水平上。因此,本提案中的研究旨在更全面地表征早期事件,这些事件触发,协调和调节植物对低氧可用性的反应,使用低氧相关细胞信号传导活动的成像,基因表达相关变化的表征以及这些细胞和分子事件中受损突变体的反应分析的综合方法。除了推进植物如何适应环境的基础知识外,该提案中的研究还将与农业长期相关,因为季节性洪水可能会因气候变化而加剧,可能成为未来作物生产力的重要因素。这项基础研究还致力于开发一种植物生物学电影资源,旨在吸引和教育公众。这项工作将密切参与本科生在电影的制作和演示。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Simon Gilroy其他文献
Root Hair Development
- DOI:
10.1007/s00344-003-0007-x - 发表时间:
2003-04-28 - 期刊:
- 影响因子:4.400
- 作者:
Tatiana Bibikova;Simon Gilroy - 通讯作者:
Simon Gilroy
A Comparison between Quin-2 and Aequorin as Indicators of Cytoplasmic Calcium Levels in Higher Plant Cell Protoplasts.
Quin-2 和水母发光蛋白作为高等植物细胞原生质体细胞质钙水平指标的比较。
- DOI:
10.1104/pp.90.2.482 - 发表时间:
1989 - 期刊:
- 影响因子:7.4
- 作者:
Simon Gilroy;W. A. Hughes;Anthony Trewavas - 通讯作者:
Anthony Trewavas
A touchy subject: Casup2+/sup signaling during leaf movements in Mimosa
一个敏感的话题:含羞草叶片运动过程中的 Casup2+/sup 信号传导
- DOI:
10.1016/j.ceca.2023.102695 - 发表时间:
2023-03-01 - 期刊:
- 影响因子:4.000
- 作者:
Arkadipta Bakshi;Sarah J. Swanson;Simon Gilroy - 通讯作者:
Simon Gilroy
Signal Transduction in Barley Aleurone Protoplasts Is Calcium Dependent and Independent.
大麦糊粉原生质体中的信号转导是钙依赖性和独立性的。
- DOI:
10.1105/tpc.8.12.2193 - 发表时间:
1996 - 期刊:
- 影响因子:0
- 作者:
Simon Gilroy - 通讯作者:
Simon Gilroy
Signal processing and transduction in plant cells: the end of the beginning?
植物细胞中的信号处理与转导:开端的终结?
- DOI:
10.1038/35067109 - 发表时间:
2001-04-01 - 期刊:
- 影响因子:90.200
- 作者:
Simon Gilroy;Anthony Trewavas - 通讯作者:
Anthony Trewavas
Simon Gilroy的其他文献
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{{ truncateString('Simon Gilroy', 18)}}的其他基金
Collaborative Research: Systemic Signailng Networks in Arabidopsis
合作研究:拟南芥系统信号网络
- 批准号:
2016177 - 财政年份:2020
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Mechanotransduction Networks in Arabidopsis
拟南芥中的力转导网络
- 批准号:
1557899 - 财政年份:2016
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Ca2+ Waves in Systemic Signaling Networks in Plants
植物系统信号网络中的 Ca2 波
- 批准号:
1329723 - 财政年份:2013
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Cellular Mechanisms of Mechanotransduction in Arabidopsis
拟南芥机械力转导的细胞机制
- 批准号:
0641288 - 财政年份:2007
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Collaborative Research: Molecular, Biochemical and Signal Transduction Analysis of a Phytotoxic Root-Root Communication Process Mediated by (-)-Catechin in the Rhizosphere
合作研究:根际 (-)-儿茶素介导的植物毒性根-根通讯过程的分子、生化和信号转导分析
- 批准号:
0750968 - 财政年份:2007
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Collaborative Research: Molecular, Biochemical and Signal Transduction Analysis of a Phytotoxic Root-Root Communication Process Mediated by (-)-Catechin in the Rhizosphere
合作研究:根际 (-)-儿茶素介导的植物毒性根-根通讯过程的分子、生化和信号转导分析
- 批准号:
0336738 - 财政年份:2004
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Multiphoton Confocal Microscope for Plant Cell Biology
用于植物细胞生物学的多光子共焦显微镜
- 批准号:
0301460 - 财政年份:2003
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Signal Transduction in Root Gravitropism
根向地性中的信号转导
- 批准号:
0212099 - 财政年份:2002
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Signal Transduction in Root Gravitropism
根向地性中的信号转导
- 批准号:
9874445 - 财政年份:1999
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Signal Transduction in Arabidopsis Root Gravitropism
拟南芥根向地性中的信号转导
- 批准号:
9513991 - 财政年份:1996
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
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