Into the Heart of an Epidemic: a US-Brazil Collaboration for Integrative Studies of the Amphibian-Killing Fungus in Brazil

深入流行病的核心:美国和巴西合作对巴西的两栖类杀死真菌进行综合研究

基本信息

项目摘要

This award supports planning meetings between several US researchers (representing the University of Michigan, Cornell University, and the University of Maine) and Brazilian colleagues (from the Universidade de Campinas and the Universidade Federal de Alagoas). The goal is to generate preliminary data for studies of the ecology and evolution of the amphibian-killing fungus, Batrachochytrium dendrobatidis (Bd), in the Atlantic Coastal Forest of Brazil. Amphibian diversity of Brazil is unparalleled at nearly 900 species, of which more than 500 occur in the less than 10% of the original Atlantic Forest that remains. Causes of species declines in the Atlantic Forest include habitat destruction and invasive species, but the contribution of the fungal disease (chytridiomycosis), which has caused global amphibian declines, is uncertain. Multiple labs are independently researching the biology of chytridiomycosis in Brazil, with initial results verifying that the disease is widespread and evidence suggesting that the genetic diversity of the pathogen in Brazil is greater than in any other country sampled to date. The Brazilian collaborators bring varied experience on chytridiomycosis in Brazil, in particular, fungal biology, amphibian evolution, amphibian ecology, and microbiology. This recently emerging amphibian fungal disease is a modern problem with little precedent (chytridiomycosis is the first vertebrate pathogen known from the phylum Chytridiomycota), and therefore a successful research strategy must include integrative approaches, combining sub-disciplines of biology that rarely interact with each other. Two meetings, one in the US and one in Brazil, are planned to bring together faculty and student researchers from the five participating laboratories.Additional funding for this activity from Brazil will permit the establishment of disease detection and quantification tools, the first such capabilities in Brazil, where the awareness and response to this invading pathogen is increasing. It will also permit seamless collaborations between Bd researchers in the two countries, by equalizing technical capabilities at US and Brazilian collaborating universities and maintaining ties among collaborating students and faculty. Numerous early-career scientists will participate in this collaborative effort. In particular, this project will give US Ph.D. students the opportunity to receive interdisciplinary training in disease ecology and be mentored by Brazilian colleagues with expertise in tropical amphibian ecology, taxonomy, and microbiology. Students in both countries will benefit from training in methods in genetics and disease dynamics, and participate directly in the development of international integrative collaborations.
该奖项支持计划几位美国研究人员(代表密歇根大学、康奈尔大学和缅因大学)和巴西同事(来自坎皮纳斯大学和阿拉戈斯联邦大学)之间的会议。目的是为研究巴西大西洋沿岸森林中的两栖动物杀伤真菌Batrachochytrium dendroatidis (Bd)的生态学和进化提供初步数据。巴西的两栖动物的多样性是无与伦比的,有近900种,其中500多种出现在不到10%的原始大西洋森林中。大西洋森林物种减少的原因包括栖息地破坏和入侵物种,但真菌疾病(壶菌病)的贡献是不确定的,它导致了全球两栖动物的减少。多个实验室正在独立研究巴西壶菌病的生物学,初步结果证实该疾病广泛存在,证据表明巴西病原体的遗传多样性比迄今为止采样的任何其他国家都要大。巴西合作者带来了巴西壶菌病的丰富经验,特别是真菌生物学,两栖动物进化,两栖动物生态学和微生物学。这种最近出现的两栖动物真菌疾病是一个现代问题,几乎没有先例(壶菌病是已知的第一种来自壶菌门的脊椎动物病原体),因此一个成功的研究策略必须包括综合方法,结合很少相互作用的生物学分支学科。计划举行两次会议,一次在美国,一次在巴西,将来自5个参与实验室的教师和学生研究人员聚集在一起。巴西为这项活动提供的额外资金将允许建立疾病检测和量化工具,这是巴西的第一个此类能力,在巴西,对这种入侵病原体的认识和反应正在增加。它还将通过平衡美国和巴西合作大学的技术能力以及保持合作学生和教师之间的联系,使两国的生物医学研究人员之间实现无缝合作。许多早期职业科学家将参与这一合作努力。特别是,该项目将使美国博士生有机会接受疾病生态学的跨学科培训,并由具有热带两栖动物生态学、分类学和微生物学专业知识的巴西同事指导。两国的学生将受益于遗传学和疾病动力学方法方面的培训,并直接参与国际综合合作的发展。

项目成果

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Timothy James其他文献

Mycoloopの先へ、これから挑戦したいこと
除了 Mycoloop,我下一步想尝试什么
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hans-Peter Grossart;Christian Wurzbacher;Timothy James;Maiko Kagami;鏡味麻衣子;鏡味麻衣子;鏡味麻衣子
  • 通讯作者:
    鏡味麻衣子
Open Circuit Potential as a Tool for the Assessment of Binding Kinetics and Reagentless Protein Quantitation.
开路潜力作为评估结合动力学和无试剂蛋白质定量的工具。
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    M. Sharafeldin;Timothy James;Jason J. Davis
  • 通讯作者:
    Jason J. Davis
Evaluating Self-paced Computational Notebooks vs. Instructor-Led Online Lectures for Introductory Computer Programming
评估自定进度的计算笔记本与讲师指导的计算机编程入门在线讲座
The Appeal to Law to Provide Public Answers to Bioethical Questions: It All Depends What Sort of Answers You Want
  • DOI:
    10.1007/s10728-007-0074-4
  • 发表时间:
    2008-01-24
  • 期刊:
  • 影响因子:
    1.600
  • 作者:
    Timothy James
  • 通讯作者:
    Timothy James

Timothy James的其他文献

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{{ truncateString('Timothy James', 18)}}的其他基金

PurSUiT: Biodiversity exploration and phylogenetic systematics of the zoosporic fungal phylum Blastocladiomycota
追求:游动孢子真菌门芽生菌门的生物多样性探索和系统发育系统学
  • 批准号:
    2403677
  • 财政年份:
    2024
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
CSBR: Ownership Transfer of University of Alabama Chytrid Culture Collection to University of Michigan
CSBR:阿拉巴马大学 Chytrid 培养物保藏中心的所有权转让给密歇根大学
  • 批准号:
    1910720
  • 财政年份:
    2019
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
PurSUiT: Discovery and phylogenetic analysis of chytrid fungi using cultures and single cells
追求:利用培养物和单细胞发现壶菌并进行系统发育分析
  • 批准号:
    1929738
  • 财政年份:
    2019
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
CSBR: Ownership Transfer of University of Maine Chytrid Fungal Collection to University of Michigan
CSBR:缅因大学 Chytrid 真菌收藏的所有权转让给密歇根大学
  • 批准号:
    1756202
  • 财政年份:
    2018
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Evolutionary Consequences of Pathogen Strain Competition in an Emerging Fungal Disease
论文研究:新兴真菌病中病原体菌株竞争的进化后果
  • 批准号:
    1601259
  • 财政年份:
    2016
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
Collaborative Research: The Zygomycetes Genealogy of Life (ZyGoLife)- the conundrum of Kingdom Fungi
合作研究:接合菌生命谱系(ZyGoLife)——真菌王国的难题
  • 批准号:
    1441677
  • 财政年份:
    2015
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
Digitization TCN: Collaborative: The Microfungi Collections Consortium: A Networked Approach toDigitizing Small Fungi with Large Impacts on the Function and Health of Ecosystems
数字化 TCN:协作:微型真菌收藏联盟:对对生态系统功能和健康产生重大影响的小型真菌进行数字化的网络方法
  • 批准号:
    1502703
  • 财政年份:
    2015
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
Unveiling the diversity and ecological role of the obligate parasitic fungi in phylum Cryptomycota
揭示隐菌门专性寄生真菌的多样性和生态作用
  • 批准号:
    1354625
  • 财政年份:
    2014
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Continuing Grant
Digitization TCN: Collaborative: The Macrofungi Collection Consortium: Unlocking a Biodiversity Resource for Understanding Biotic Interactions, Nutrient Cycling and Human Affairs
数字化 TCN:协作:大型真菌收集联盟:解锁生物多样性资源以了解生物相互作用、养分循环和人类事务
  • 批准号:
    1206134
  • 财政年份:
    2012
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant
Digitization TCN Collaborative Research: North American Lichens and Bryophytes: Sensitive Indicators of Environmental Quality and Change
数字化 TCN 合作研究:北美地衣和苔藓植物:环境质量和变化的敏感指标
  • 批准号:
    1115030
  • 财政年份:
    2011
  • 资助金额:
    $ 5.47万
  • 项目类别:
    Standard Grant

相似国自然基金

e-Heart仿真平台及关键技术研究
  • 批准号:
    60571025
  • 批准年份:
    2005
  • 资助金额:
    24.0 万元
  • 项目类别:
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具有移动心室壁的先进建模平台可加快心脏泵的上市速度
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职业:受折纸启发的组织工程心脏瓣膜设计
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