Unravelling the molecular diversity and evolution of centipede venoms

揭示蜈蚣毒液的分子多样性和进化

• 批准号: DP160104025
• 负责人: Prof Glenn King
• 金额: $ 22.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104025
• 关键词: Unravelling; molecular; diversity; evolution; centipede

The project intends to improve understanding of venom evolution in centipedes. Venoms have emerged as a rich source of pharmacological tools with potential for development into therapeutics and bioinsecticides. However, venoms-based discovery has been limited by the narrow taxonomical range of animals studied, with many groups of venomous animals overlooked. One such group is centipedes, whose venoms contain diverse toxins that differ between taxa. This project aims to provide an insight into centipede venom evolution, and how it might be constrained by venom-gland morphology. This study seeks to contribute to our understanding of protein evolution and direct biodiscovery efforts around centipede venom.

该项目旨在提高对蜈蚣毒液进化的理解。毒液已成为药理学工具的丰富来源，具有开发成治疗剂和生物杀虫剂的潜力。然而，基于毒液的发现受到所研究动物的狭窄分类范围的限制，许多有毒动物被忽视。蜈蚣就是这样的一个群体，它们的毒液含有不同的毒素，这些毒素在分类群之间是不同的。这个项目的目的是提供一个深入了解蜈蚣毒液的进化，以及它如何可能受到毒液腺形态的限制。这项研究旨在促进我们对蛋白质进化的理解，并直接围绕蜈蚣毒液进行生物发现。