Development of selective blockers of acid sensing ion channel 1a for the treatment of stroke

开发用于治疗中风的酸敏感离子通道 1a 选择性阻断剂

• 批准号: nhmrc : 1063798
• 负责人: Prof Glenn King
• 金额: $ 46.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-selective-blockers-treatment-stroke/455085
• 关键词: Development; selective; blockers; acid; sensing

Stroke is the second leading cause of death worldwide. In addition, stroke causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Unfortunately, no effective neuroprotective therapy is currently available for stroke patients. In this project we plan to develop novel neuroprotective agents that are effective even when used many hours after stroke, thus providing a wide therapeutic time window for treatment of stroke patients.

中风是全球第二大死亡原因。此外，由于中风期间遭受的脑损伤，中风导致幸存受害者的残疾发生率极高。不幸的是，目前没有有效的神经保护疗法可用于中风患者。在这个项目中，我们计划开发新的神经保护剂，即使在中风后许多小时使用也有效，从而为中风患者的治疗提供广泛的治疗时间窗。