Imaging the world of miniature venomous arthropods

想象微型有毒节肢动物的世界

• 批准号: LP140100832
• 负责人: Prof Glenn King
• 金额: $ 29.88万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-11-19 至 2017-11-18
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100832
• 关键词: Imaging; world; miniature; venomous; arthropods

Venomous arthropods produce a myriad of biologically active peptides, with many having potential as pharmacological tools, bioinsecticides and pharmaceuticals. Most studies to date have focussed on large arthropods; smaller species remain neglected due to the difficulties of venom collection. This project seeks to further advance the pioneering imaging mass spectrometry approaches the project team developed for imaging toxins in the venom glands of spiders and centipedes. By combining high-resolution matrix-assisted laser desorption ionisation imaging data with histological and transcriptomic information the project aims to provide the first detailed insights into the neglected world of miniature arthropod venoms. The approaches developed by this project aim to have wide application in the field of biology.

有毒节肢动物产生大量的生物活性多肽，其中许多具有潜在的药理工具、生物杀虫剂和药物。到目前为止，大多数研究都集中在大型节肢动物上；由于毒液收集的困难，较小的物种仍然被忽视。该项目旨在进一步推进项目组为蜘蛛和蜈蚣毒腺中的毒素成像而开发的开创性成像质谱学方法。通过将高分辨率基质辅助激光解吸电离成像数据与组织学和转录学信息相结合，该项目旨在提供对被忽视的微型节肢动物毒液世界的首次详细见解。本项目所开发的方法旨在在生物学领域中有广泛的应用。