Electrophysiology Platform for Ion-channel Characterisation

用于离子通道表征的电生理学平台

• 批准号: LE200100190
• 负责人: Prof Glenn King
• 金额: $ 41.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-08-04 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE200100190
• 关键词: Electrophysiology; Platform; Ion; channel; Characterisation

Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.

离子通道是普遍存在的成孔膜蛋白，人类基因组编码>300个离子通道。离子通道的不同作用包括动作电位的产生、控制穿过分泌细胞和上皮细胞的离子流以及调节细胞体积、运动性和增殖。药理学调节剂是探测离子通道功能的有力工具，但对于大多数通道，这些工具是缺乏的。因此，本项目的目的是开发第一个全面的工具箱离子通道调节剂使用集成的体外/体内电生理平台。这些药理学工具将免费提供给澳大利亚研究界，用于探索离子通道的机制和生理功能。