Venoms to drugs: translating venom peptides into human therapeutics

毒液到药物：将毒液肽转化为人类疗法

• 批准号: nhmrc : 1136889
• 负责人: Prof Glenn King
• 金额: $ 52.37万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/venoms-drugs-translating-human-therapeutics/1318507
• 关键词: Venoms; drugs; translating; venom; peptides

Many disorders of the nervous system, including chronic pain, epilepsy and the neuronal degeneration suffered following a stroke, result from malfunction of channels that ferry ions across neuronal cell membranes. There are very few drugs available for treating these disorders and they often have debilitating side-effects. We are developing potent and selective modulators of these ion channels as the next-generation of safe and effective analgesic, anti-epileptic, and neuroprotective drugs.

神经系统的许多疾病，包括慢性疼痛、癫痫和中风后遭受的神经元变性，都是由将离子运送穿过神经元细胞膜的通道功能障碍引起的。有很少的药物可用于治疗这些疾病，他们往往有衰弱的副作用。我们正在开发这些离子通道的有效和选择性调节剂，作为下一代安全有效的镇痛，抗癫痫和神经保护药物。