Gain from pain: new tools from venomous animals for exploring pain pathways

从痛苦中获益：有毒动物探索疼痛途径的新工具

• 批准号: DP190103787
• 负责人: Prof Glenn King
• 金额: $ 28.43万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2022-01-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103787
• 关键词: Gain; pain; new; tools; venomous

This project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to uncover toxins that employ new mechanisms of pain signalling, leading to new insights into pain physiology.

该项目旨在探索动物毒液中新的致痛毒素，以确定其结构和作用机制。许多有毒的动物使用它们的毒液防御和envenomation往往是与快速和往往难以忍受的疼痛。在大多数情况下，它们实现这一点的分子机制是未知的。利用生物化学、药理学和生物物理学技术，该项目有望发现采用疼痛信号新机制的毒素，从而对疼痛生理学产生新的见解。