Triple R connection of geminivirus multiplication

双生病毒增殖的三重R连接

• 批准号: 206285263
• 负责人: Professor Dr. Holger Jeske (†)
• 金额: --
• 依托单位: Forschungseinheit Molekulare und Synthetische Pflanzenvirologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206285263?language=en
• 关键词: Triple; connection; geminivirus; multiplication

The triple R connection of replication, recombination and repair provided geminiviruses the potential to become one of the most important pathogens of crop plants of the world, mainly in the tropical and subtropical belt. High mutation and recombination rates of these viruses are thought to be the major driving forces of their evolution and thus of their epidemics. Their multiplication relies widely on host genes which will be identified in the proposed project by profiting from the available Arabidopsis thaliana mutants, from virus-induced gene silencing (VIGS), and three recently discovered begomovirus isolates and their alphasatellites which infect efficiently and induce only mild symptoms in A. thaliana.

双生病毒复制、重组和修复的三重R连接为双生病毒成为全球主要热带和亚热带作物最重要的病原体之一提供了可能。这些病毒的高突变率和重组率被认为是它们进化的主要驱动力，因此也是它们流行的主要驱动力。它们的繁殖广泛依赖于宿主基因，这些基因将在拟议的项目中通过利用可用的拟南芥突变体、病毒诱导的基因沉默（VIGS）和最近发现的三个菜豆花叶病毒分离物及其在A. thaliana.

项目成果

A Population Genetics Perspective on Geminivirus Infection

• DOI: 10.1128/jvi.01956-15
• 发表时间: 2015-12-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Weigel, Karin;Pohl, Jens O.;Jeske, Holger
• 通讯作者: Jeske, Holger

Somatic homologous recombination in plants is promoted by a geminivirus in a tissue-selective manner.

双生病毒以组织选择性方式促进植物中的体细胞同源重组

• DOI: 10.1016/j.virol.2014.01.024
• 发表时间: 2014
• 期刊: Virology
• 影响因子: 3.7
• 作者: Richter;Kleinow
• 通讯作者: Kleinow

Form follows function in geminiviral minichromosome architecture.

双子病毒微型染色体结构中的形式遵循功能

• DOI: 10.1016/j.virusres.2014.11.004
• 发表时间: 2015
• 期刊: Virus research
• 影响因子: 5
• 作者: Paprotka;Deuschle;Pilartz
• 通讯作者: Pilartz

KU80, a key factor for non-homologous end-joining, retards geminivirus multiplication.

KU80是非同源末端连接的关键因素，可阻碍双生病毒增殖

• DOI: 10.1099/jgv.0.000224
• 发表时间: 2015
• 期刊: The Journal of general virology
• 作者: Richter

Rad54 is not essential for any geminiviral replication mode in planta

Rad54 对于植物中的任何双生病毒复制模式都不是必需的

• DOI: 10.1007/s11103-014-0270-1
• 发表时间: 2015
• 期刊: Plant Molecular Biology
• 影响因子: 5.1
• 作者: Richter