Triple R connection of geminivirus multiplication

双生病毒增殖的三重R连接

• 批准号: 206285263
• 负责人: Professor Dr. Holger Jeske (†)
• 金额: --
• 依托单位: Forschungseinheit Molekulare und Synthetische Pflanzenvirologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206285263?language=en
• 关键词: Triple; connection; geminivirus; multiplication

The triple R connection of replication, recombination and repair provided geminiviruses the potential to become one of the most important pathogens of crop plants of the world, mainly in the tropical and subtropical belt. High mutation and recombination rates of these viruses are thought to be the major driving forces of their evolution and thus of their epidemics. Their multiplication relies widely on host genes which will be identified in the proposed project by profiting from the available Arabidopsis thaliana mutants, from virus-induced gene silencing (VIGS), and three recently discovered begomovirus isolates and their alphasatellites which infect efficiently and induce only mild symptoms in A. thaliana.

复制、重组和修复的三重R连接使双生病毒有可能成为世界上农作物最重要的病原体之一，主要分布在热带和亚热带地区。这些病毒的高突变率和重组率被认为是其进化及其流行的主要驱动力。它们的增殖广泛依赖于宿主基因，这些宿主基因将在拟议的项目中通过利用现有的拟南芥突变体、病毒诱导的基因沉默（VIGS）以及最近发现的三种贝戈莫病毒分离株及其α卫星来识别，这些病毒可有效感染拟南芥并仅诱导轻微症状。

项目成果

A Population Genetics Perspective on Geminivirus Infection

• DOI: 10.1128/jvi.01956-15
• 发表时间: 2015-12-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Weigel, Karin;Pohl, Jens O.;Jeske, Holger
• 通讯作者: Jeske, Holger

Somatic homologous recombination in plants is promoted by a geminivirus in a tissue-selective manner.

双生病毒以组织选择性方式促进植物中的体细胞同源重组

• DOI: 10.1016/j.virol.2014.01.024
• 发表时间: 2014
• 期刊: Virology
• 影响因子: 3.7
• 作者: Richter;Kleinow
• 通讯作者: Kleinow

Form follows function in geminiviral minichromosome architecture.

双子病毒微型染色体结构中的形式遵循功能

• DOI: 10.1016/j.virusres.2014.11.004
• 发表时间: 2015
• 期刊: Virus research
• 影响因子: 5
• 作者: Paprotka;Deuschle;Pilartz
• 通讯作者: Pilartz

KU80, a key factor for non-homologous end-joining, retards geminivirus multiplication.

KU80是非同源末端连接的关键因素，可阻碍双生病毒增殖

• DOI: 10.1099/jgv.0.000224
• 发表时间: 2015
• 期刊: The Journal of general virology
• 作者: Richter

Rad54 is not essential for any geminiviral replication mode in planta

Rad54 对于植物中的任何双生病毒复制模式都不是必需的

• DOI: 10.1007/s11103-014-0270-1
• 发表时间: 2015
• 期刊: Plant Molecular Biology
• 影响因子: 5.1
• 作者: Richter