MRI: Acquisition of a single-crystal diffractometer for the University of Minnesota

MRI：为明尼苏达大学购买一台单晶衍射仪

• 批准号: 1229400
• 负责人: John Ellis
• 金额: $ 25.59万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229400&HistoricalAwards=false
• 关键词: MRI; Acquisition; single; crystal; diffractometer

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor John Ellis from University of Minnesota-Twin Cities and colleagues Lawrence Que, William Tolman, Calvin Sun and Connie Lu will acquire a single crystal diffractometer with a compact copper radiation source, photon detector and a top-of-the-line cryostat capable of collecting high-resolution diffraction data on very small specimens. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) hydrocarbon-stabilized metal-atom reagents; (b) electron-transfer molecular catalysts; (c) bioinorganic studies of metallo-copper enzymes and synthesis of sustainable polymeric materials; (d) study and optimization of the physico-mechanical properties of drugs; (e) model complexes of non-heme iron metalloenzymes; (f) design of biologically active agents; (g) synthetic routes to biologically active compounds; (h) Pro-Leu-Gly-NH2 and dopamine receptor modulation study and anthrax toxin lethal factor inhibition; and (i) study of parthenolide and helenalin analogues.An X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research not only at the University of Minnesota but also at neighboring colleges and universities in the Twin Cities area.

该奖项由化学研究仪器和设施（CRIF）项目共同资助，来自明尼苏达大学双城分校的John Ellis教授和他的同事Lawrence Que、William Tolman、Calvin Sun和Connie Lu将获得一个单晶衍射仪，该衍射仪具有紧凑的铜辐射源、光子探测器和顶级低温恒温器，能够在非常小的样品上收集高分辨率的衍射数据。这项建议的目的是加强各级的研究培训和教育，特别是在以下领域：(a)碳氢化合物稳定金属原子试剂；(b)电子转移分子催化剂；(c)金属铜酶的生物无机研究和可持续聚合材料的合成；(d)药物物理力学性能的研究与优化；(e)非血红素铁金属酶模型配合物；(f)生物活性制剂的设计；(g)生物活性化合物的合成途径；(h) Pro-Leu-Gly-NH2和多巴胺受体调节研究及炭疽毒素致死因子抑制；和(i)研究parthenolide和hellenalin类似物。x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。这台仪器不仅将成为明尼苏达大学的教学和研究的一个组成部分，而且也将成为双子城地区邻近学院和大学的教学和研究的一个组成部分。

项目成果

Bimetallic nickel-lutetium complexes: tuning the properties and catalytic hydrogenation activity of the Ni site by varying the Lu coordination environment

双金属镍镥配合物：通过改变Lu配位环境来调节Ni位点的性能和催化加氢活性

• DOI: 10.1039/c8sc04712j
• 发表时间: 2019
• 期刊: Chemical Science
• 影响因子: 8.4
• 作者: Ramirez, Bianca L.;Sharma, Prachi;Eisenhart, Reed J.;Gagliardi, Laura;Lu, Connie C.
• 通讯作者: Lu, Connie C.

Reductive Disproportionation of CO 2 Mediated by Bimetallic Nickelate(-I)/Group 13 Complexes: Reductive Disproportionation of CO 2 Mediated by Bimetallic Nickelate(-I)/Group 13 Complexes

双金属镍酸盐(-I)/第13族配合物介导的CO 2 还原歧化: 双金属镍酸盐(-I)/第13族配合物介导的CO 2 还原歧化

• DOI: 10.1002/ejic.201801452
• 发表时间: 2019
• 期刊: European Journal of Inorganic Chemistry
• 影响因子: 2.3
• 作者: Vollmer, Matthew V.;Cammarota, Ryan C.;Lu, Connie C.
• 通讯作者: Lu, Connie C.