ERASynBio: BioMolecular Origami

ERASynBio:生物分子折纸

基本信息

  • 批准号:
    1445201
  • 负责人:
  • 金额:
    $ 38.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-07-15 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

This project, funded by the Systems and Synthetic Biology Program in MCB and the Biotechnology, Biochemical and Biomass Engineering Program in CBET, is part of a larger ERASynBio funded collaborative. The team of investigators will develop the rules that govern the design of complex nanometer scale structures made from nucleic acids and polypeptides, and use those rules to create new biological molecules that have never been seen before in nature. They will also develop the tools that will enable the assembly of these new materials that could potentially be used to control many aspects of cell function, or create new materials that could be used as sensors or in biomanufacturing.Technical: Biological organisms are capable of producing chemicals, materials and molecular machines that far exceed our engineering capabilities. Underlying these abilities are the unique properties of proteins, exquisitely evolved for function, allowing precise positioning of atoms and chemistries. Designing novel proteins is difficult because of our still incomplete understanding of how proteins fold for a given primary amino-acid sequence. In this project, researchers will apply principles of synthetic biology to define and modularize building blocks that can be combined in rational ways to enable control of 3D positioning in designed macromolecular structure. Members of the consortium have advanced design and engineering principles for polypeptide- and DNA-based nanostructures and developed next-generation gene synthesis to facilitate high-throughput approaches. The team will build on these foundations to engineer bio-macromolecular assemblies with shapes and functions of unprecedented complexity. They will deliver an expanded toolbox of polypeptide building elements; rules, design principles and methods for constructing complex bionanostructures; and routes to nucleic acid/ polypeptide-hybrid platforms for the community of synthetic biology. The project will expand the limits of the designed polypeptide and nucleic acid/protein hybrid providing a platform to facilitate their use in a wide range of biomanufacturing applications.
该项目由MCB的系统和合成生物学计划以及CBET的生物技术,生物化学和生物质工程计划资助,是ERASynBio资助的更大合作的一部分。研究小组将制定规则,管理由核酸和多肽制成的复杂纳米级结构的设计,并使用这些规则来创造自然界中从未见过的新生物分子。 他们还将开发能够组装这些新材料的工具,这些新材料可能用于控制细胞功能的许多方面,或创造可用作传感器或生物制造的新材料。技术:生物有机体能够生产远远超过我们工程能力的化学品,材料和分子机器。这些能力的基础是蛋白质的独特性质,它们为了功能而精心进化,允许原子和化学物质的精确定位。设计新的蛋白质是困难的,因为我们仍然不完全了解蛋白质如何折叠给定的一级氨基酸序列。在这个项目中,研究人员将应用合成生物学的原理来定义和模块化构建块,这些构建块可以以合理的方式组合,以控制设计的大分子结构中的3D定位。该联盟的成员拥有基于多肽和DNA的纳米结构的先进设计和工程原理,并开发了下一代基因合成以促进高通量方法。 该团队将在这些基础上构建具有前所未有的复杂形状和功能的生物大分子组装体。他们将提供多肽构建元素的扩展工具箱;构建复杂生物纳米结构的规则,设计原则和方法;以及合成生物学社区的核酸/多肽杂交平台的路线。该项目将扩大设计的多肽和核酸/蛋白质杂交体的限制,提供一个平台,以促进其在广泛的生物制造应用中的使用。

项目成果

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David Baker其他文献

Designed repeat protein in complex with Fz7
设计与 Fz7 复合的重复蛋白
  • DOI:
    10.2210/pdb6ne2/pdb
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    16.8
  • 作者:
    Luke T. Dang;Y. Miao;A. Ha;Kanako Yuki;K. Park;C. Y. Janda;K. Jude;K. Mohan;N. Ha;Mario Vallon;Jenny Yuan;J. Vilches;C. Kuo;K. Garcia;David Baker
  • 通讯作者:
    David Baker
Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family.
克氏锥虫腺苷酸环化酶由复杂的多基因家族编码。
VaxCelerate II: Rapid development of a self-assembling vaccine VaxCelerate II: Rapid development of a self-assembling vaccine for Lassa fever for Lassa fever
VaxCelerate II:快速开发拉沙热自组装疫苗 VaxCelerate II:快速开发拉沙热自组装疫苗
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Pierre Leblanc;L. Moise;Cybelle Luza;Kanawat Chantaralawan;Lynchy Lezeau;Jianping Yuan;M. Field;Daniel Richer;C. Boyle;William D Martin;Jordan B Fishman;Eric A Berg;David Baker;Brandon Zeigler;Dale E Mais;William Taylor;Russell Coleman;Shaw Warren;Jeffrey A. Gelfand;A. S. D. Groot;Timothy Brauns;M. Poznansky
  • 通讯作者:
    M. Poznansky
Big History’s Big Potential
大历史的大潜力
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    L. Grinin;David Baker;E. Quaedackers;Andrey Korotayev
  • 通讯作者:
    Andrey Korotayev
Engaging a community to focus on upper limb function in people with multiple sclerosis: the ThinkHand campaign case study
让社区关注多发性硬化症患者的上肢功能:ThinkHand 活动案例研究
  • DOI:
    10.1186/s40900-024-00586-y
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Alison Thomson;Rachel Horne;Christine Chapman;Trishna Bharadia;Patrick Burke;Elizabeth Colwell;Mark Harrington;Bonnie Boskovic;Andrea M Stennett;David Baker;Gavin Giovannoni;K. Schmierer
  • 通讯作者:
    K. Schmierer

David Baker的其他文献

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{{ truncateString('David Baker', 18)}}的其他基金

MFB: Deep-Learning Enabled Structure Prediction and Design of Protein-DNA Assemblies
MFB:深度学习支持蛋白质-DNA 组装的结构预测和设计
  • 批准号:
    2226466
  • 财政年份:
    2022
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
Co-production of a software tool for field-scale species distribution modelling (fs-SDM) and mapping using local biodiversity records
共同开发用于野外规模物种分布建模 (fs-SDM) 和使用当地生物多样性记录进行绘图的软件工具
  • 批准号:
    NE/V007726/1
  • 财政年份:
    2020
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Fellowship
CIBR: Collaborative Research: CIBR Expanding structure coverage of genomes to facilitate macromolecular assembly determination.
CIBR:协作研究:CIBR 扩大基因组的结构覆盖范围,以促进大分子组装测定。
  • 批准号:
    1937533
  • 财政年份:
    2019
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
Generation, functionalization, and distribution of de novo designed protein nanomaterials
从头设计的蛋白质纳米材料的生成、功能化和分布
  • 批准号:
    1629214
  • 财政年份:
    2016
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
RAPID: Empowering the Citizen Scientist in the Fight Against Ebolaviruses
RAPID:赋予公民科学家抗击埃博拉病毒的能力
  • 批准号:
    1523362
  • 财政年份:
    2015
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
I-Corps: Enterprise Rosetta Protein Modelling and Design Software on the Cloud
I-Corps:云端企业 Rosetta 蛋白质建模和设计软件
  • 批准号:
    1507114
  • 财政年份:
    2014
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
DMREF Integrating theory, computation and experiment to robustly design complex protein-based nanomaterials
DMREF 整合理论、计算和实验,稳健地设计复杂的基于蛋白质的纳米材料
  • 批准号:
    1332907
  • 财政年份:
    2013
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
SBIR Phase II: Serious Gaming Platform for Mastering the Physician-Patient Diagnostic Interview
SBIR 第二阶段:掌握医患诊断访谈的严肃游戏平台
  • 批准号:
    1230418
  • 财政年份:
    2012
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
Identical Particles and Statistics in Superselection Theory
超选择理论中的相同粒子和统计
  • 批准号:
    1127260
  • 财政年份:
    2011
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant
SBIR Phase I: Serious Gaming Platform for Mastering the Physician-Patient Diagnostic Interview
SBIR 第一阶段:掌握医患诊断访谈的严肃游戏平台
  • 批准号:
    1046589
  • 财政年份:
    2011
  • 资助金额:
    $ 38.88万
  • 项目类别:
    Standard Grant

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Atomistic reconstruction of large biomolecular systems from low-resolution cryo-electron microscopy data - RECKON
利用低分辨率冷冻电子显微镜数据原子重建大型生物分子系统 - RECKON
  • 批准号:
    EP/Y010221/1
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职业:设计纳米颗粒界面以实现可调节的生物分子聚集
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生殖细胞中 mRNA 调节的生物分子凝聚体
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REU 网站:波多黎各化学学习融入材料和生物分子应用 (PR-CLIMB)
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职业:生物分子拓扑的实验和计算研究
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职业:稳定生物分子缩合物的表面活性剂蛋白:从生物物理学到生物制造的生物材料
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