Social experience: effects on auditory filtering through a serotonergic mechanism

社会经验：通过血清素能机制对听觉过滤的影响

• 批准号: 1456298
• 负责人: Laura Hurley
• 金额: $ 62.74万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1456298&HistoricalAwards=false
• 关键词: Social; experience; effects; auditory; filtering

In addition to its well-known roles in regulating mood and appetite, the chemical serotonin plays an important role in the response of the brain to social interaction. Despite this, very little is known about its role in a crucial type of social behavior, communication. In their past work, the researchers have shown that serotonin modifies auditory responses to communication calls in mice, and that social partners trigger these increases in serotonin in the auditory system. In other regions of the brain, the serotonergic system itself is heavily influenced by past social experience. With this rationale, the researchers hypothesize that social experience changes the role of the serotonergic system in auditory processing. They will test this idea by measuring how housing mice individually or in social groups affects the way that the serotonergic system interacts with the auditory system. This work will explore a process fundamental to communication: how sensory systems adapt to features of the social environment like social history, with implications for how animals respond to their social partners. The work will also serve as a springboard for a local K-12 outreach program in which undergraduates present interactive lessons on themes of communication and sensory systems.The social experience hypothesis will be tested in male and female mice, which are increasingly studied models of vocal communication. Mice also demonstrate highly conserved serotonergic function in auditory regions compared with other vertebrates. The specific objectives of the proposed work are to examine the effect of group versus individual housing on three features of serotonin-auditory interactions in the inferior colliculus (IC), a mammalian auditory midbrain nucleus. 1) The first of these is the anatomy of the serotonergic system within the IC. This will be accomplished by measuring the density of immunohistochemically labeled serotonergic fibers. 2) A second feature is the transient serotonergic response to social interactions. This will be measured locally in the IC of behaving animals using carbon fiber voltammetry. 3) A final feature is the serotonergic regulation of the activation of the c-fos transcriptional pathway by social interaction, which will be explored by inducing systemic release or depletion of serotonin. These studies will provide a framework of how social experience creates plasticity in auditory-serotonin interactions at multiple levels of organization, generating testable hypotheses on the downstream consequences of such plasticity for neural encoding and perception.

除了众所周知的调节情绪和食欲的作用外，化学血清素在大脑对社会互动的反应中也起着重要作用。尽管如此，人们对它在一种至关重要的社会行为——交流中所起的作用知之甚少。在他们过去的工作中，研究人员已经表明，血清素会改变老鼠对交流呼叫的听觉反应，而社交伙伴会引发听觉系统中血清素的增加。在大脑的其他区域，血清素能系统本身受到过去社会经验的严重影响。根据这一理论，研究人员假设社会经验改变了血清素系统在听觉处理中的作用。他们将通过测量单独或群居老鼠如何影响血清素能系统与听觉系统的相互作用来验证这一观点。这项工作将探索沟通的一个基本过程：感觉系统如何适应社会环境的特征，如社会历史，以及动物如何对其社会伙伴做出反应。这项工作还将作为当地K-12扩展计划的跳板，在该计划中，本科生将讲授交流和感官系统主题的互动课程。社会经验假说将在雄性和雌性老鼠身上进行测试，这是越来越多的研究声音交流的模型。与其他脊椎动物相比，小鼠在听觉区域也表现出高度保守的血清素能功能。该研究的具体目标是研究群体与个体住房对哺乳动物听觉中脑核下丘（IC）中血清素-听觉相互作用的三个特征的影响。1)首先是对IC内5 -羟色胺能系统的解剖。这将通过测量免疫组织化学标记的5 -羟色胺能纤维的密度来完成。2)第二个特征是对社会交往的短暂的血清素能反应。这将在行为动物的IC中使用碳纤维伏安法进行局部测量。3)最后一个特征是5 -羟色胺能通过社会互动调节c-fos转录通路的激活，这将通过诱导5 -羟色胺的全身释放或消耗来探索。这些研究将为社会经验如何在多层次组织中创造听觉-血清素相互作用的可塑性提供一个框架，并对这种可塑性对神经编码和感知的下游后果产生可测试的假设。

项目成果

Postweaning Isolation Alters the Responses of Auditory Neurons to Serotonergic Modulation

• DOI: 10.1093/icb/icab051
• 发表时间: 2021-05-11
• 期刊: INTEGRATIVE AND COMPARATIVE BIOLOGY
• 影响因子: 2.6
• 作者: Davis, Sarah E. D.;Sansone, Jack M.;Hurley, Laura M.
• 通讯作者: Hurley, Laura M.

Non-sensory Influences on Auditory Learning and Plasticity

• DOI: 10.1007/s10162-022-00837-3
• 发表时间: 2022-03-02
• 期刊: JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
• 影响因子: 2.4
• 作者: Caras，Melissa L.;Happel，Max F. K.;Wright，Beverly A.
• 通讯作者: Wright，Beverly A.

Social Experience Interacts with Serotonin to Affect Functional Connectivity in the Social Behavior Network following Playback of Social Vocalizations in Mice

• DOI: 10.1523/eneuro.0247-20.2021
• 发表时间: 2021-03
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Christopher L. Petersen;Sarah E. D. Davis;Bhumi Patel;L. Hurley

Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice

• DOI: 10.1016/j.brainres.2018.05.010
• 发表时间: 2018-09-01
• 期刊: BRAIN RESEARCH
• 影响因子: 2.9
• 作者: Keesom, Sarah M.;Morningstar, Mitchell D.;Hurley, Laura M.
• 通讯作者: Hurley, Laura M.