SBIR RAPID: Filovirus Ebola Simulants to help improve the effectiveness and reliability of personal protective equipment for protection from Ebola exposure.

SBIR RAPID：丝状病毒埃博拉模拟物有助于提高个人防护设备的有效性和可靠性，以防止接触埃博拉病毒。

• 批准号: 1506898
• 负责人: David Schultz
• 金额: $ 14.87万
• 依托单位: Seashell Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506898&HistoricalAwards=false
• 关键词: SBIR; RAPID; Filovirus; Ebola; Simulants

The proposed research will lead to a more thorough characterization of the effectiveness, or lack thereof, of currently utilized protective equipment for personnel in contact with Ebola virus infected individuals. This knowledge will have immediate benefit to medical personnel and allow for the identification of suitable protective equipment that will protect both medical personnel and other persons who are subject to exposure to Ebola. This work will lead to novel assay systems that can be integrated into standard quality control assessment of existing medical protective materials, and allow for protective performance assessment of unique super water repellent materials, manufactured and sold by Seashell Technology, to Ebola simulants. A significant societal benefit will be attained by the ability to deliver a novel, inexpensive, improved barrier that can be supplied to individuals in impacted areas. The use of these materials in infected areas will have the potential to significantly lower Ebola transmission rates, lead to control of the epidemic, curtail the economic consequences associated with the current epidemic, and reduce deaths and suffering. These same materials will have significant benefit for control of future potential Ebola breakouts. The objectives of this research project are to determine the protective performance of medically relevant barriers to penetration by individually optically trackable Ebola viral simulants. This will provide an opportunity to increase the tools that can be used to study this deadly class of viruses. The work proposed has significant potential to advance our knowledge of the spread of Ebola and the types of protective equipment that will block viral penetration. The Ebola virus has a unique rod-shaped morphology, unlike any other strain of virus; therefore standard methods of modeling viral barrier effectiveness cannot be accurately interpreted. Seashell Technology's ability to manufacture the individually optically trackable Ebola viral simulants and extensive knowledge of this type of particles dispersion properties provide a unique opportunity to better assess the potential spread of Ebola. Additionally, the protective performance to Ebola penetration of an inexpensive super water repellent breathable fabric, created using a nanostructured coating material that can be economically and rapidly manufactured by Seashell Technology, will be assessed. Should this fabric provide excellent protection from Ebola exposure there is an opportunity to supply this protective material to persons in the areas impacted by the epidemic and significantly reduce the transmission of Ebola.

拟议的研究将导致对目前使用的保护设备的有效性或缺乏效率的人，以更全面地表征与埃博拉病毒感染的人接触的人员。这些知识将对医务人员立即受益，并允许识别合适的防护设备，这些防护设备将保护医务人员和其他受埃博拉病毒的接触。这项工作将导致新颖的测定系统，可以将其集成到现有医疗保护材料的标准质量控制评估中，并允许对Seashell Technology制造和出售的独特超级驱动物材料进行保护性绩效评估，并向埃博拉模拟物。通过提供新颖，廉价，改进的障碍的能力，可以为受影响地区的个人提供，将获得重大的社会利益。在感染区域中使用这些材料将有可能显着降低埃博拉传播率，导致控制流行病，减少与当前流行病有关的经济后果，并减少死亡和痛苦。这些相同的材料将对未来潜在的埃博拉病毒的爆发有重大好处。 该研究项目的目标是通过单独的可追踪埃博拉病毒模拟物来确定医学相关障碍的保护性能。这将为增加可用于研究这种致命类病毒的工具提供机会。拟议的工作具有巨大的潜力，可以提高我们对埃博拉病毒传播的了解以及会阻止病毒渗透的保护设备的类型。与其他任何其他病毒不同，埃博拉病毒具有独特的杆状形态。因此，无法准确解释对病毒屏障有效性进行建模的标准方法。 Seashell Technology能够制造单独的光学跟踪埃博拉病毒模拟物以及对这种类型的颗粒分散性能的广泛了解，这为更好地评估埃博拉病毒的潜在传播提供了独特的机会。此外，将评估使用纳米结构化涂层材料制成的廉价超级驱动透气织物的保护性能，该材料将在经济上可以通过贝壳技术在经济上迅速生产。如果这种织物可提供极大的保护免受埃博拉病毒的影响，则有机会向受流行病影响的地区的人提供这种保护材料，并大大减少了埃博拉病毒的传播。