SBIR RAPID: Filovirus Ebola Simulants to help improve the effectiveness and reliability of personal protective equipment for protection from Ebola exposure.

SBIR RAPID：丝状病毒埃博拉模拟物有助于提高个人防护设备的有效性和可靠性，以防止接触埃博拉病毒。

• 批准号: 1506898
• 负责人: David Schultz
• 金额: $ 14.87万
• 依托单位: Seashell Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506898&HistoricalAwards=false
• 关键词: SBIR; RAPID; Filovirus; Ebola; Simulants

The proposed research will lead to a more thorough characterization of the effectiveness, or lack thereof, of currently utilized protective equipment for personnel in contact with Ebola virus infected individuals. This knowledge will have immediate benefit to medical personnel and allow for the identification of suitable protective equipment that will protect both medical personnel and other persons who are subject to exposure to Ebola. This work will lead to novel assay systems that can be integrated into standard quality control assessment of existing medical protective materials, and allow for protective performance assessment of unique super water repellent materials, manufactured and sold by Seashell Technology, to Ebola simulants. A significant societal benefit will be attained by the ability to deliver a novel, inexpensive, improved barrier that can be supplied to individuals in impacted areas. The use of these materials in infected areas will have the potential to significantly lower Ebola transmission rates, lead to control of the epidemic, curtail the economic consequences associated with the current epidemic, and reduce deaths and suffering. These same materials will have significant benefit for control of future potential Ebola breakouts. The objectives of this research project are to determine the protective performance of medically relevant barriers to penetration by individually optically trackable Ebola viral simulants. This will provide an opportunity to increase the tools that can be used to study this deadly class of viruses. The work proposed has significant potential to advance our knowledge of the spread of Ebola and the types of protective equipment that will block viral penetration. The Ebola virus has a unique rod-shaped morphology, unlike any other strain of virus; therefore standard methods of modeling viral barrier effectiveness cannot be accurately interpreted. Seashell Technology's ability to manufacture the individually optically trackable Ebola viral simulants and extensive knowledge of this type of particles dispersion properties provide a unique opportunity to better assess the potential spread of Ebola. Additionally, the protective performance to Ebola penetration of an inexpensive super water repellent breathable fabric, created using a nanostructured coating material that can be economically and rapidly manufactured by Seashell Technology, will be assessed. Should this fabric provide excellent protection from Ebola exposure there is an opportunity to supply this protective material to persons in the areas impacted by the epidemic and significantly reduce the transmission of Ebola.

拟议的研究将导致对目前使用的与埃博拉病毒感染者接触的人员的防护设备的有效性或缺乏有效性进行更彻底的表征。这一知识将对医务人员产生直接效益，并有助于确定适当的防护设备，以保护医务人员和其他可能接触埃博拉病毒的人员。这项工作将导致新的检测系统，可以集成到现有医疗防护材料的标准质量控制评估中，并允许评估由Seashell Technology制造和销售的独特超级防水材料对埃博拉模拟物的防护性能。一个显著的社会效益将实现的能力，提供一个新的，廉价的，改进的障碍，可以提供给个人在受影响的地区。在感染地区使用这些材料将有可能大大降低埃博拉病毒的传播率，控制疫情，减少与当前疫情相关的经济后果，并减少死亡和痛苦。这些相同的材料将对控制未来潜在的埃博拉爆发具有重大益处。 本研究项目的目的是确定医学相关屏障对可单独光学跟踪的埃博拉病毒模拟物渗透的保护性能。这将为增加可用于研究这类致命病毒的工具提供机会。拟议的工作有很大的潜力，以提高我们对埃博拉病毒传播的认识，以及阻止病毒渗透的防护设备类型。埃博拉病毒具有独特的杆状形态，与任何其他病毒株不同;因此，无法准确解释病毒屏障有效性建模的标准方法。Seashell Technology能够制造可单独光学跟踪的埃博拉病毒模拟物，并对这种类型的颗粒分散特性有广泛的了解，这为更好地评估埃博拉病毒的潜在传播提供了独特的机会。此外，还将评估一种廉价的超级防水透气织物对埃博拉病毒渗透的保护性能，这种织物使用Seashell Technology可以经济快速地制造的纳米结构涂层材料制成。如果这种织物能提供良好的保护，使人们免受埃博拉病毒的感染，就有机会向受疫情影响地区的人们提供这种保护材料，并大大减少埃博拉病毒的传播。