Materials World Network: Structural design and micromechanical properties of mechanotransducing biological materials

材料世界网络：力传导生物材料的结构设计和微机械性能

• 批准号: 220144857
• 负责人: Professorin Dr. Yael Politi, Ph.D.
• 金额: --
• 依托单位: B CUBE - Center for Molecular Bioengineering
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/220144857?language=en
• 关键词: Materials; World; Network; Structural; design

The merit of the project is in the understanding of principles found in natural vibrational receptors and the mechanism of mechanical signal detection from the spider slit biosensory system at the material level. The investigation of the direct spatial correlation among cuticule morphology, hierarchical structural organization and spatial distribution of micromechanical properties in spider stress-sensing slit-sensilla will be a crucial point of this project. We will explore the time-dependent micromechanical properties of these mechano-receptors embedded in the spider exoskeleton with high spatial resolution (down to a few nanometers) and relate the findings to the function of these organs as sensitive and selective vibration filters. We suggest that the micromechanical properties of the cuticle, which are dependent on the protein nanofiber arrangement and orientation as well as the properties of the protein matrix around the slits, are key parameters for the time-dependent mechanical response during slit compression and the efficient transmittance and filtering of external mechanical stimuli. Ultimately, this knowledge can be utilized in the future design and development of bio-inspired mechanoresponsive and adaptive nanostructured materials. In our study, we will address several important questions: How do the spatial chemical composition and molecular/supramolecular structural organization of biological materials define localized mechanical properties? How can time-dependent mechanical behavior of biosensory receptors be correlated with sensitive high-pass filtering properties? What are the limits of spatial and deformational detection in biomaterials under vibrational stimuli? Which major elements of elastic, viscoelastic, and dynamic deformational modes of biomaterials might be considered for future bioinspired design of synthetic hierarchical adaptive materials?

该项目的优点在于理解了自然振动受体的原理，以及在材料水平上从蜘蛛缝生物感觉系统检测机械信号的机制。研究蜘蛛应力传感裂隙传感器角质层形态、层次结构组织和微力学性能空间分布之间的直接空间相关性将是本项目研究的重点。我们将以高空间分辨率（低至几纳米）探索嵌入蜘蛛外骨骼中的这些机械感受器的时间依赖微力学特性，并将这些发现与这些器官作为敏感和选择性振动过滤器的功能联系起来。我们认为，角质层的微观力学特性是决定狭缝压缩过程中随时间变化的力学响应以及外部机械刺激的有效透射和过滤的关键参数，而微观力学特性取决于蛋白质纳米纤维的排列和取向以及狭缝周围蛋白质基质的特性。最终，这些知识可以用于未来设计和开发仿生机械响应和自适应纳米结构材料。在我们的研究中，我们将解决几个重要的问题：生物材料的空间化学成分和分子/超分子结构组织如何定义局部力学性能？生物感觉受体的时间依赖性机械行为如何与敏感的高通滤波特性相关联？在振动刺激下，生物材料的空间和变形检测的局限性是什么？生物材料的弹性、粘弹性和动态变形模式的哪些主要元素可能被考虑用于未来的合成分层自适应材料的仿生设计？

项目成果

Micromechanical properties of strain-sensitive lyriform organs of a wandering spider (Cupiennius salei).

• DOI: 10.1016/j.actbio.2016.06.009
• 发表时间: 2016-09
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Seth L. Young;Marius Chyasnavichyus;F. Barth;I. Zlotnikov;Yael Politi;V. Tsukruk

A spider's biological vibration filter: micromechanical characteristics of a biomaterial surface.

• DOI: 10.1016/j.actbio.2014.07.023
• 发表时间: 2014-11
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Seth L. Young;Marius Chyasnavichyus;M. Erko;F. Barth;P. Fratzl;I. Zlotnikov;Yael Politi;V. Tsukruk