UNS:A Multi-Element ICP-MS Approach for Detection of Engineered Nanoparticles in the Environment

UNS：用于检测环境中工程纳米颗粒的多元素 ICP-MS 方法

• 批准号: 1512695
• 负责人: James Ranville
• 金额: $ 31.22万
• 依托单位: Colorado School of Mines
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1512695&HistoricalAwards=false
• 关键词: UNS; Multi; Element; ICP; MS

#1512695Ranville, James F.Water, soil, and air all contain ultrafine particles, nanoparticles, that are far smaller than the width of a human hair. Nature creates nanoparticles constantly, and we may now be adding to this background of tiny particles by our development of nanotechnology. We put highly engineered nanoparticles in our medicines, foods, textiles, sunscreens, and many other products. This project seeks to use highly-developed analytical methods, along with developments in sampling of waters and sediments, to detect and quantify the nanoparticles released from nanotechnology and discriminate them from those created naturally.This project will utilize recent developments in new nanometrologies to overcome the challenges (e.g. small size, low concentration, interfering natural NPs (NNPs)) for quantifying engineered nanoparticles (ENPs) in aquatic systems. Several new approaches to single-particle ICP-MS (spICP-MS) analysis, which have the capability to detect multiple elements on a particle-by-particle basis, will provide new data that will allow significant progress in risk assessment of nanotechnology. The analytical approach utilizes elemental composition differences, which exist between ENPs and the interfering NNPs, to provide ENP identification and quantification. The detection of multiple elements in NNPs will distinguish them from the simpler (single) element detection events characteristic of ENPs. The current "background" surface water NP concentrations (particle number, mass) and NP characteristics (e.g. size distribution, composition) will be determined. Heteroaggregation experiments, facilitated by multi-element spICP-MS analysis, will also be performed to establish how it effects the proposed nanometrologies and will also provide needed information on ENP fate in surface water. Collectively, this information is currently missing but critically important for determining the environmental health and safety effects of ENPs. The research will be a collaboration with two established groups in research (USGS) and in public education (RiverWatch). Information acquired is expected to (i) reduce uncertainty in risk assessment of nanotechnology, (ii) provide the framework for performing ENP analysis within the USGS sampling network, with the ultimate goal of incorporating methodology from QUANT-Nano into routine water quality monitoring, (iii) through summer research experiences at CSM and field-trips we will train a diverse group of K-12 students and high school science teachers to "see the invisible" by developing simple experiments that educate about small particles in water. We will involve these students and educators in the monitoring of their local water resources, and (iv) educate the public on the importance of environmental monitoring to facilitate safe development of nanotechnology,

#1512695兰维尔，詹姆斯F.水，土壤和空气都含有超细颗粒，纳米颗粒，远远小于人类头发的宽度。大自然不断地创造纳米粒子，而我们现在可能正在通过发展纳米技术来增加这种微小粒子的背景。我们在药品、食品、纺织品、防晒霜和许多其他产品中加入了高度工程化的纳米颗粒。该项目寻求使用高度发达的分析方法，以及水和沉积物采样的发展，来检测和量化纳米技术释放的纳米颗粒，并将它们与自然产生的纳米颗粒区分开来。该项目将利用新的纳米计量学的最新发展来克服在水生系统中量化工程纳米颗粒(ENPs)的挑战(例如，小尺寸、低浓度、干扰天然NPs(NNPs))。单粒子电感耦合等离子体质谱(SPICP-MS)分析的几种新方法能够逐个粒子地检测多种元素，它们将提供新的数据，使纳米技术的风险评估能够取得重大进展。该分析方法利用ENPs和干扰NNPs之间存在的元素组成差异来提供ENP的识别和定量。检测核动力源中的多种元素将使它们有别于核动力源所特有的更简单的(单一)元素检测事件。将确定当前的“背景”地表水NP浓度(颗粒数量、质量)和NP特性(例如，粒度分布、组成)。还将在多元素SPICPMS分析的帮助下进行异质聚集实验，以确定它如何影响拟议的纳米技术，并将提供关于ENP在地表水中去向的必要信息。总的来说，这些信息目前尚不存在，但对于确定环境、健康和安全对环境的影响至关重要。这项研究将与研究(USGS)和公共教育(RiverWatch)两个老牌组织合作。预计获得的信息将有助于：(I)减少纳米技术风险评估的不确定性；(Ii)为在USGS采样网络内进行ENP分析提供框架，最终目标是将Quant-Nano的方法纳入常规水质监测；(Iii)通过CSM的夏季研究经验和实地考察，我们将培训不同的K-12学生和高中科学教师通过开发简单的实验来“看不见”水中的小颗粒。我们将让这些学生和教育工作者参与监测他们当地的水资源，并(Iv)教育公众环境监测的重要性，以促进纳米技术的安全发展，