Die Rolle von tertiären lymphatischen Geweben bei Entzündungsreaktionen und entzündlichen Erkrankungen im Darm

三级淋巴组织在肠道炎症反应和炎症性疾病中的作用

• 批准号: 22053038
• 负责人: Privatdozent Dr. Matthias Lochner
• 金额: --
• 依托单位: Développement des Tissues Lymphoides
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/22053038?language=en
• 关键词: Die; Rolle; von; terti; ren

The development of lymphoid tissues recapitulates the inflammatory reaction and culminates in the formation of complex lymphoid aggregates. The development of lymph nodes and Peyer¿s patches in the gut is programmed and is initiated in the sterile environment of the fetus. In contrast, the formation of tertiary lymphoid tissues is induced by infection. Chronic inflammation also leads to tertiary lymphoid tissue formation, in which many different cells types interact, such as B cells, T cells, myeloid and stromal cells. The goal of this project is to understand the mechanisms that lead to formation of tertiary lymphoid tissues and their impact on inflammatory disease. To achieve this, I will use existing mouse models and also develop new transgenic approaches to examine the phenomena of tertiary lymphoid tissue formation in the context of intestinal inflammation. The specific aims of this project are to (1) identify the inflammatory triggers of tertiary lymphoid tissue formation and visualize the molecular and cellular interactions during tertiary lymphoid tissue formation. (2) to prevent intestinal inflammation by blocking the formation of lymphoid tissues. The long-term aim is to develop new and specific tools for the control of pathologic inflammation, such as occurs in inflammatory bowel disease, rheumatoid arthritis or multiple sclerosis.

淋巴组织的发育重演炎症反应，最终形成复杂的淋巴集合体。肠内淋巴结和佩耶S斑块的发育是程序化的，并在胎儿的无菌环境中启动。相反，第三级淋巴组织的形成是由感染诱导的。慢性炎症还会导致第三级淋巴组织的形成，其中许多不同类型的细胞相互作用，如B细胞、T细胞、髓样细胞和基质细胞。这个项目的目标是了解导致第三级淋巴组织形成的机制及其对炎症性疾病的影响。为了实现这一点，我将使用现有的小鼠模型，并开发新的转基因方法来研究肠道炎症背景下第三级淋巴组织形成的现象。本项目的具体目标是(1)确定三级淋巴组织形成的炎症诱因，并可视化三级淋巴组织形成过程中的分子和细胞相互作用。(2)通过阻断淋巴组织的形成来预防肠道炎症。长期目标是开发新的特定工具来控制病理性炎症，如炎症性肠病、类风湿性关节炎或多发性硬化症。