MRI: Acquisition of a Liquid Chromatography-Mass Spectrometry System for Research and Research Training

MRI：获取用于研究和研究培训的液相色谱-质谱系统

• 批准号: 1531851
• 负责人: Sundeep Rayat
• 金额: $ 19.7万
• 依托单位: Ball State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1531851&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatography; Mass

With this award from the Major Research Instrumentation (MRI) and Chemistry Research Instrumentation and Facilities (CRIF) programs, Ball State University will acquire a liquid chromatography-mass ppectrometry (LC-MS) system. The system is used to determine the composition of mixtures of materials obtained from various sources including samples obtained from chemical syntheses, environmental or biological sources. In this instrument the liquid chromatograph (LC) separates the complex mixture into its individual components, then mass spectrometer (MS) is used to determine the mass of the components by measuring the mass to charge ratio (m/z) of ions produced from the components. LC-MS is a powerful analytical tool for finding out what the components are in a complex sample. The instrument will be used by students in their research, training them for its usage in their careers. It will also be used in outreach to disabled students and underrepresented groups.The instrument will be used in research especially in areas such as (a) characterizating nitrogen heterocycles for materials and medicine; (b) designing RNA nanovehicles for drug delivery in phototherapy; (c) studying photochemistry of organic pollutants at air-water interface; (d) determining the role of mammalian CDC42 in cell signaling pathways with implications in bacterial infections; (e) understanding of the mechanism of apolipoprotein beta degradation with relevance to cholesterol related pathologies; (f) studying nanoparticle catalyzed photodegradation of organic compounds for environmental remediation; and (g) enabling the elucidating chemistry emanating from highly reactive aryl nitrenes and oxypyridinium salts to access synthetically useful motifs.

通过主要研究仪器（MRI）和化学研究仪器和设施（CRIF）计划的这一奖项，鲍尔州立大学将获得液相色谱-质谱（LC-MS）系统。该系统用于确定从各种来源获得的材料混合物的组成，包括从化学合成、环境或生物来源获得的样品。在该仪器中，液相色谱仪（LC）将复杂混合物分离成其单个组分，然后质谱仪（MS）用于通过测量从组分产生的离子的质荷比（m/z）来确定组分的质量。LC-MS是一种强大的分析工具，用于找出复杂样品中的成分。该仪器将被学生用于他们的研究，培训他们在职业生涯中使用。它还将用于对残疾学生和代表性不足的群体的外展。该仪器将用于研究，特别是在以下领域：（a）表征材料和医学中的氮杂环;（B）设计用于光疗中药物输送的RNA纳米载体;（c）研究空气-水界面有机污染物的光化学;（d）确定哺乳动物CDC 42在细胞信号传导途径中的作用，其在细菌感染中具有暗示性;（e）理解与胆固醇相关的病理学相关的载脂蛋白β降解的机制;（f）研究用于环境修复的有机化合物的纳米颗粒催化的光降解;以及（g）使得能够阐明源自高反应性芳基氮烯和氧基吡啶鎓盐的化学物质以获得合成有用的基序。