MRI: Acquisition of a Liquid Chromatography-Mass Spectrometry System for Research and Research Training

通过主要研究仪器（MRI）和化学研究仪器和设施（CRIF）项目的资助，波尔州立大学将获得一套液相色谱-质谱（LC-MS）系统。该系统用于确定从各种来源获得的材料混合物的组成，包括从化学合成、环境或生物来源获得的样品。在该仪器中，液相色谱仪（LC）将复杂的混合物分离成其单独的组分，然后使用质谱仪（MS）通过测量组分产生的离子的质量电荷比（m/z）来确定组分的质量。LC-MS是一种强大的分析工具，可以找出复杂样品中的成分。该仪器将用于学生的研究，训练他们在他们的职业生涯中使用。它还将用于向残疾学生和代表性不足的群体提供服务。该仪器将用于研究，特别是在以下领域：(a)表征材料和药物的氮杂环；(b)设计用于光疗药物递送的RNA纳米载体；(c)研究空气-水界面有机污染物的光化学；(d)确定哺乳动物CDC42在细菌感染的细胞信号通路中的作用；(e)了解载脂蛋白β降解与胆固醇相关病理的机制；(f)纳米颗粒催化有机化合物光降解的环境修复研究；(g)使高活性芳基亚硝基和氧吡啶盐产生的解析化学能够获得合成上有用的基序。

With this award from the Major Research Instrumentation (MRI) and Chemistry Research Instrumentation and Facilities (CRIF) programs, Ball State University will acquire a liquid chromatography-mass ppectrometry (LC-MS) system. The system is used to determine the composition of mixtures of materials obtained from various sources including samples obtained from chemical syntheses, environmental or biological sources. In this instrument the liquid chromatograph (LC) separates the complex mixture into its individual components, then mass spectrometer (MS) is used to determine the mass of the components by measuring the mass to charge ratio (m/z) of ions produced from the components. LC-MS is a powerful analytical tool for finding out what the components are in a complex sample. The instrument will be used by students in their research, training them for its usage in their careers. It will also be used in outreach to disabled students and underrepresented groups.The instrument will be used in research especially in areas such as (a) characterizating nitrogen heterocycles for materials and medicine; (b) designing RNA nanovehicles for drug delivery in phototherapy; (c) studying photochemistry of organic pollutants at air-water interface; (d) determining the role of mammalian CDC42 in cell signaling pathways with implications in bacterial infections; (e) understanding of the mechanism of apolipoprotein beta degradation with relevance to cholesterol related pathologies; (f) studying nanoparticle catalyzed photodegradation of organic compounds for environmental remediation; and (g) enabling the elucidating chemistry emanating from highly reactive aryl nitrenes and oxypyridinium salts to access synthetically useful motifs.