CAREER: Evolution of Morphological Diversity in Primates as revealed by 3D Digital Data, Comprehensive Datasets, and Automated Phenotyping
职业:3D 数字数据、综合数据集和自动表型分析揭示灵长类动物形态多样性的演变
基本信息
- 批准号:1552848
- 负责人:
- 金额:$ 49.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this CAREER award Dr. Doug Boyer, along with collaborators, will collect data on primate skeletons in the form of 3D digital imagery of museum specimens and apply newly developed algorithmic methods to analyze and interpret the evolutionary meaning of those data. This research will address fundamental questions about how modern primate diversity came to be, work to refine understanding of the incremental processes that differentiated humanity from its closest relatives. As a result of this research 3D digital models will be added to Duke?s virtual museum (www.morphosource.org), which is accessible to all researchers and the public; the bioinformatics analysis tools his team is developing will enable researchers to analyze and interpret data on geometrically complex aspects anatomical diversity. Boyer will simultaneously work with education scientists connecting this virtual museum to educators and students in ways that emphasize STEM learning and Next Generation Science Standards. In addition, the virtual museum -- open to contributions from any scientist -- will provide a forum where researchers can easily disseminate their data (and theoretical advances stemming from it) to educators and public.In Boyer's 5-year project he will execute studies targeting hypotheses central to perceptions of how primates evolved: 1) Influence of dietary ecology on primate characteristics: mechanical properties of tooth geometry will be quantified and their evolutionary tempo and mode will be modeled across living and fossil primates to see whether a diet of insects or herbaceous material has driven various episodes of diversification. The team will also evaluate whether certain other distinctive features of primate skeletons can be related to dietary needs or other biological roles by assessing patterns of covariation among all traits of interest. 2) Influence of functional constraints on patterns of evolution: Boyer and his team will determine how anatomical solutions to ecological problems in ancestral primates have affected subsequent paths of diversification by running analyses that compare magnitudes and patterns of variation among different regions of the skeleton across primates. This project will contribute multiple studies introducing a new paradigm for testing evolutionary hypotheses. Additionally, it creates a novel bioinformatics infrastructure that democratizes access to morphological datasets and enables a broader community of researchers to analyze such data, setting the stage for synchronizing morphological studies with genomic ones, and will ultimately maximizing the explanatory power of research utilizing morphology to gain insight on evolutionary processes. In particular, molecular and evolutionary-developmental biologists will be able to evaluate the significance of morphological variation associated with genetic and gene-expression data, and biomedical engineers will be able to automate measurement protocols and evaluate variation in their data more rapidly and efficiently.
在这个CAREER奖项中,Doug Boyer博士与合作者沿着,将以博物馆标本的3D数字图像的形式收集灵长类动物骨骼的数据,并应用新开发的算法方法来分析和解释这些数据的进化意义。这项研究将解决有关现代灵长类动物多样性如何形成的基本问题,致力于完善对人类与其最近亲属区分的渐进过程的理解。作为这项研究的结果,三维数字模型将被添加到杜克?www.morphosource.org他的团队正在开发的生物信息学分析工具将使研究人员能够分析和解释关于解剖学多样性的几何复杂方面的数据。Boyer将同时与教育科学家合作,以强调STEM学习和下一代科学标准的方式将这个虚拟博物馆与教育工作者和学生联系起来。此外,虚拟博物馆--向任何科学家开放--将提供一个论坛,研究人员可以很容易地传播他们的数据在Boyer的5年项目中,他将执行针对灵长类动物如何进化的核心假设的研究:1)饮食生态学对灵长类动物特征的影响:牙齿几何形状的机械特性将被量化,它们的进化克里思和模式将在活的和化石灵长类动物中被建模,以了解昆虫或草本材料的饮食是否推动了多样化的各种事件。研究小组还将通过评估所有感兴趣的特征之间的协变模式来评估灵长类骨骼的某些其他独特特征是否与饮食需求或其他生物学作用有关。2)功能约束对进化模式的影响:Boyer和他的团队将通过分析比较灵长类动物骨骼不同区域之间的变化幅度和模式,确定祖先灵长类动物生态问题的解剖学解决方案如何影响随后的多样化路径。这个项目将贡献多项研究,为测试进化假说引入一个新的范式。此外,它创建了一个新的生物信息学基础设施,使形态数据集的访问民主化,并使更广泛的研究人员社区能够分析这些数据,为同步形态学研究与基因组研究奠定基础,并最终最大限度地提高利用形态学研究的解释力,以深入了解进化过程。 特别是,分子和进化发育生物学家将能够评估与遗传和基因表达数据相关的形态变异的意义,生物医学工程师将能够自动化测量方案,并更快速有效地评估数据中的变异。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Douglas Boyer其他文献
Douglas Boyer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Douglas Boyer', 18)}}的其他基金
Doctoral Dissertation Research: The shape of hands and feet and the transition to upright walking
博士论文研究:手脚的形状以及直立行走的过渡
- 批准号:
2316552 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Building Capacity in MorphoSource through state-of-art, flexible data storage protocols for broader and more sustainable adoption by museums and other mass-data producers.
通过最先进、灵活的数据存储协议建设 MorphoSource 的能力,以便博物馆和其他海量数据生产者更广泛、更可持续地采用。
- 批准号:
2311380 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Continuing Grant
Sustaining MorphoSource 3D data Repository: Supporting a transformation in research and education practices relying on biodiversity and natural history collections
维持 MorphoSource 3D 数据存储库:支持依赖生物多样性和自然历史收藏的研究和教育实践转型
- 批准号:
2149257 - 财政年份:2022
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Collaborative Research: Measuring leaping performance, evaluating its anatomical correlates, and reconsidering the importance of leaping in primate origins and early evolution
合作研究:测量跳跃表现,评估其解剖学相关性,并重新考虑跳跃在灵长类起源和早期进化中的重要性
- 批准号:
2020434 - 财政年份:2021
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
COLLABORATIVE PROPOSAL:ABI DEVELOPMENT: AN INTEGRATED PLATFORM FOR RETRIEVAL, VISUALIZATION AND ANALYSIS OF 3D MORPHOLOGY FROM DIGITAL BIOLOGICAL COLLECTIONS
合作提案:ABI 开发:数字生物馆藏 3D 形态检索、可视化和分析的综合平台
- 批准号:
1759839 - 财政年份:2018
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Encephalic Arterial Canals and their Functional Significance
博士论文研究:脑动脉管及其功能意义
- 批准号:
1825129 - 财政年份:2018
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Descent Locomotion Behavior in Primates
博士论文研究:灵长类动物的下降运动行为
- 批准号:
1751686 - 财政年份:2018
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
ABI Development: Collaborative Research: The first open access digital archive for high fidelity 3D data on morphological phenomes
ABI 开发:协作研究:第一个开放存取数字档案,用于形态学现象的高保真 3D 数据
- 批准号:
1661386 - 财政年份:2017
- 资助金额:
$ 49.81万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Generation and Evaluation of Body Mass Prediction Equations Using Articular Surface Areas of the Primate Tarsus
博士论文研究:利用灵长类跗骨关节表面积生成和评估体重预测方程
- 批准号:
1540421 - 财政年份:2015
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Collaborative Research: Reassessing Primate Origins through Digital Investigation of Eocene Fossils from the Bridger Basin, Wyoming
合作研究:通过对怀俄明州布里杰盆地始新世化石的数字调查重新评估灵长类动物起源
- 批准号:
1440742 - 财政年份:2014
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
相似国自然基金
Galaxy Analytical Modeling
Evolution (GAME) and cosmological
hydrodynamic simulations.
- 批准号:
- 批准年份:2025
- 资助金额:10.0 万元
- 项目类别:省市级项目
Understanding structural evolution of galaxies with machine learning
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
The formation and evolution of planetary systems in dense star clusters
- 批准号:11043007
- 批准年份:2010
- 资助金额:10.0 万元
- 项目类别:专项基金项目
Improving modelling of compact binary evolution.
- 批准号:10903001
- 批准年份:2009
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: RUI: Uncovering eusocial pathways and consequences: Phylogenomics, morphological, and molecular evolution in Synalpheus snapping shrimps.
合作研究:RUI:揭示真社会途径和后果:鳄虾的系统基因组学、形态学和分子进化。
- 批准号:
2345470 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
NSF PRFB FY23: Polyploidy as a driver of developmental and morphological evolution
NSF PRFB FY23:多倍体作为发育和形态进化的驱动力
- 批准号:
2305732 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Fellowship Award
Process of flipper formation in secondary aquatic adaptation modeled on morphological evolution in pinnipeds
以鳍足类形态进化为模型的二次水生适应过程中鳍状肢的形成过程
- 批准号:
22KJ0145 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Morphological evolution and the Cambrian Explosion - a 550 million year view
形态演化与寒武纪大爆发——5.5亿年的视角
- 批准号:
NE/W007878/2 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Fellowship
Collaborative Research: The role of multifunctionality in the evolution of cranial morphological diversity in bats
合作研究:多功能性在蝙蝠颅骨形态多样性进化中的作用
- 批准号:
2336218 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Continuing Grant
Morphological evolution and the Cambrian Explosion - a 550 million year view
形态演化与寒武纪大爆发——5.5亿年的视角
- 批准号:
NE/W007878/1 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Fellowship
Collaborative Research: RUI: Uncovering eusocial pathways and consequences: Phylogenomics, morphological, and molecular evolution in Synalpheus snapping shrimps.
合作研究:RUI:揭示真社会途径和后果:鳄虾的系统基因组学、形态学和分子进化。
- 批准号:
2306958 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Uncovering eusocial pathways and consequences: Phylogenomics, morphological, and molecular evolution in Synalpheus snapping shrimps.
合作研究:RUI:揭示真社会途径和后果:鳄虾的系统基因组学、形态学和分子进化。
- 批准号:
2306957 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Revealing the Physical Drivers of Morphological Evolution with AI/Machine Learning and Rubin Observatory
通过人工智能/机器学习和鲁宾天文台揭示形态进化的物理驱动因素
- 批准号:
2307158 - 财政年份:2023
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant
Collaborative Research: The role of multifunctionality in the evolution of cranial morphological diversity in bats
合作研究:多功能性在蝙蝠颅骨形态多样性进化中的作用
- 批准号:
2202272 - 财政年份:2022
- 资助金额:
$ 49.81万 - 项目类别:
Standard Grant