MRI: Acquisition of a super-resolution microscope for Boston College

MRI：为波士顿学院购买超分辨率显微镜

• 批准号: 1626072
• 负责人: Laura Anne Lowery
• 金额: $ 45.44万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626072&HistoricalAwards=false
• 关键词: MRI; Acquisition; super; resolution; microscope

An award is made to Boston College to support the acquisition of a Super-Resolution Structured Illumination Microscope that will be shared by researchers in the Biology, Chemistry, Physics and Psychology departments. Each of the co-PIs on this grant trains multiple undergraduates every year, and these undergraduates will benefit dramatically from experience using a super-resolution microscope. Furthermore, this microscope will be used as a general training and recruitment platform to draw more undergraduates from diverse backgrounds into life-science. Specifically, the microscope will be directly incorporated into the undergraduate curriculum via the Advanced Cellular Imaging Course which enrolls 24 students annually. Additionally, the microscope will be incorporated into many outreach efforts run by faculty in the department including Research Day for Under-represented Students and the Women in Science and Technology Program. Finally, a collaboration has been initiated with Wellesley College, a highly competitive college for women, which will have access to this microscope for research projects, and will include in the class Modern Biological Imaging, which trains 12 women every year. Thus, enrichment of undergraduate training in general, and for women and under-represented groups specifically, is a primary function of this instrument.Super-resolution microscopy is crucial to cell biological research today. This fact is highlighted by entire sessions at international meetings such as the American Society for Cell Biology Annual Meeting being devoted to the technique, and by the volume of manuscripts that would not be possible without the spatial resolution made possible by super-resolution microscopy. Boston College has a critical mass of cell biologists, and a well-equipped, University-funded, imaging facility. The addition of Super-Resolution Microscopy capabilities will expand the questions that can be asked, and the depth to which questions can be addressed. Furthermore, it will be a tool for the recruitment of new faculty, postdoctoral fellows, and graduate students. In conclusion, super-resolution capabilities are necessary, not only to drive cell based research today, but to properly train future scientists. The SR-SIM system at Boston College will be maximized for both goals and will additionally be used as a tool to develop collaborations between faculty and students at a number of area institutions.

波士顿学院获得了一个奖项，以支持获得一个超分辨率结构照明显微镜，该显微镜将由生物学、化学、物理学和心理学系的研究人员共享。该补助金的每个合作PI每年都会培训多名本科生，这些本科生将从使用超分辨率显微镜的经验中受益匪浅。此外，这台显微镜将被用作一个通用的培训和招聘平台，吸引更多来自不同背景的本科生进入生命科学领域。具体来说，显微镜将直接纳入本科课程通过高级细胞成像课程，每年招收24名学生。此外，显微镜将被纳入该部门教师开展的许多外联工作，包括代表性不足的学生研究日和妇女参与科学技术计划。最后，还与竞争激烈的女子学院韦尔斯利学院开展了合作，该学院将有机会使用这种显微镜进行研究项目，并将现代生物成像列入课程，该课程每年培训12名妇女。因此，丰富本科生的培训，特别是妇女和代表性不足的群体，是这台仪器的主要功能。超分辨率显微镜是至关重要的细胞生物学研究的今天。这一事实在国际会议上得到了强调，例如美国细胞生物学学会年会专门讨论该技术，以及如果没有超分辨率显微镜的空间分辨率，就不可能有大量的手稿。波士顿学院拥有大量的细胞生物学家，以及设备齐全的大学资助的成像设施。超分辨率显微镜功能的增加将扩大可以提出的问题，以及可以解决问题的深度。此外，它还将成为招聘新教师、博士后研究员和研究生的工具。总之，超分辨率能力是必要的，不仅是为了推动当今基于细胞的研究，而且是为了适当地培养未来的科学家。波士顿学院的SR-SIM系统将最大限度地实现这两个目标，并将作为一种工具，在一些地区机构发展教师和学生之间的合作。