CSBR: Living Stock: Enhancement to the operation and accessibility of the Algal Resources Collection

CSBR：活畜：增强藻类资源收集的运作和可及性

• 批准号: 1756414
• 负责人: Catharina Alves-de-Souza
• 金额: $ 42.61万
• 依托单位: University of North Carolina at Wilmington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1756414&HistoricalAwards=false
• 关键词: CSBR; Living; Stock; Enhancement; operation

Toxic algae have serious negative effects varying from fish kills to human illnesses caused by the consumption of shellfish contaminated with algal toxins. The economic impact from blooms of these algae can be devastating to fishing and shellfish industries and tourism. However, bioactive compounds and molecules produced by these toxic algae have also become an interesting and exciting avenue for innovative basic and applied research. The Algal Resources Collection (ARC) at the University of North Carolina Wilmington is the only public collection exclusively dedicated to toxic microalgae in the United States. Currently comprising 424 algal strains, ARC is a major supplier of toxic algae strains for scientists all over the world. Cultures have been extensively used by national and international research community in studies encompassing diverse subject areas, including ecology, taxonomy and phylogeny, comparative genomics, studies on the effects of algal toxins on human and animal health, and for the development of toxin profiles. Cultures are also used to develop alternative solutions for the monitoring and remediation of toxic algae and toxins, as well as in the search of new bioactive compounds in the development of new drugs to treat or cure a variety of diseases. Additionally, ARC researchers and staff are involved in outreach activities that involve diverse educational levels including K-12 teachers and students, undergraduate, graduate and PhD students.This project seeks to optimize the functionality and accessibility of the ARC as a Living Stocks resource. The main goals are: 1) Enhancement of infrastructure and procedures for the improvement of culturing conditions and workflow efficiency, 2) Improvement of the collection organization and curation practices, and 3) Increase the visibility of the collection to the research community. These improvements will allow ARC to offer their unique cultures to a much larger portion of this scientific community, to take the final step towards the consolidation of the ARC as a community research resource, and to achieve the self-sustainability necessary for its maintenance and expansion.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

有毒藻类具有严重的负面影响，从鱼类死亡到因食用受藻类毒素污染的贝类而引起的人类疾病。 这些藻类大量繁殖对渔业、贝类产业和旅游业的经济影响可能是毁灭性的。 然而，这些有毒藻类产生的生物活性化合物和分子也成为创新基础和应用研究的一个有趣和令人兴奋的途径。 北卡罗来纳州威尔明顿大学的藻类资源收集中心（ARC）是美国唯一专门致力于有毒微藻的公共收集中心。 ARC目前拥有424种藻类菌株，是世界各地科学家有毒藻类菌株的主要供应商。 培养物已被国家和国际研究界广泛用于涵盖不同主题领域的研究，包括生态学、分类学和遗传学、比较基因组学、藻类毒素对人类和动物健康影响的研究以及毒素概况的开发。 培养物还用于开发替代解决方案，用于监测和补救有毒藻类和毒素，以及在开发治疗或治愈各种疾病的新药中寻找新的生物活性化合物。 此外，ARC的研究人员和工作人员参与了涉及不同教育水平的外展活动，包括K-12教师和学生，本科生，研究生和博士生。该项目旨在优化ARC作为活种群资源的功能和可访问性。 主要目标是：1）加强基础设施和程序，以改善培养条件和工作流程效率，2）改善收藏组织和策展实践，3）提高收藏对研究界的可见度。 这些改进将使ARC能够向这个科学界的更大部分提供他们独特的文化，朝着巩固ARC作为社区研究资源的方向迈出最后一步，并实现自我-该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响进行评估，被认为值得支持审查标准。

项目成果

First examination of sterols in the marine dinoflagellate genus Vulcanodinium

• DOI: 10.1111/jeu.12863
• 发表时间: 2021-06
• 期刊: Journal of Eukaryotic Microbiology
• 影响因子: 2.2
• 作者: Stephanie L. Vandergrift;Lindsey C. Elkins;C. Alves-de-Souza;Jeffrey D. Leblond

Comparative characterization of three Tetraselmis chui (Chlorophyta) strains as sources of nutraceuticals

• DOI: 10.1007/s10811-021-02675-x
• 发表时间: 2022-01-11
• 期刊: JOURNAL OF APPLIED PHYCOLOGY
• 影响因子: 3.3
• 作者: Oliveira Moser, Gleyci A.;Barrera-Alba, Jose Juan;Bartual, Ana
• 通讯作者: Bartual, Ana