Amplifying light emission with metal-fluorophore nanostructures for ultrasensitive biosensing

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This proposal focuses on translating nanotechnology to ultrasensitive molecular monitoring for biomedicine. We will apply a new tool, amplified fluorophores to proteomics where they will provide an improved method for early detection and understanding of diseases through molecular fingerprints. The project will also generate an ultra-sensitive, rapid technology that can be used for personalized point-of-care diagnostics. The applications can include the detection of disease markers, pathogens or the determination of protein content in a clinical sample. These technologies will be applicable across a spectrum or of diseases all of which will benefit the broader community.