The colour of cellular aging: a deep probe of cellular processes

细胞衰老的颜色：细胞过程的深入探索

• 批准号: DP210102960
• 负责人: Prof Ewa Goldys
• 金额: $ 35.21万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102960
• 关键词: colour; cellular; aging; deep; probe

Understanding why we age and whether aging is preventable are profound research challenges, which must be first tackled at a cellular level. Building on our advances in non-invasive colour monitoring of cell function, this project aims to uncover intimate links between cellular processes and aging in cells that must survive for many decades such as oocytes and neurons. We will explore the tantalising possibility to rejuvenate such aged cells by interfering with molecular master switches of aging. A unique machine learning approach will be applied for finding the most effective interventions. The results will have broad impact beyond the science of aging, in the areas of female fertility, neurodegeneration and immunity.

了解我们为什么会衰老以及衰老是否可以预防是一项深刻的研究挑战，必须首先在细胞水平上解决。基于我们在细胞功能的非侵入性颜色监测方面的进展，该项目旨在揭示细胞过程与必须存活数十年的细胞（如卵母细胞和神经元）衰老之间的密切联系。我们将探索通过干扰衰老的分子主开关来恢复这些衰老细胞的诱人可能性。将采用独特的机器学习方法来寻找最有效的干预措施。研究结果将在女性生育力、神经退化和免疫力等领域产生广泛的影响，而不仅仅是衰老科学。