Understanding gender differences in pain: Cellular therapies for animal pain

了解疼痛的性别差异：动物疼痛的细胞疗法

• 批准号: LP160100562
• 负责人: Prof Ewa Goldys
• 金额: $ 23.65万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-12-16 至 2021-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100562
• 关键词: Understanding; gender; differences; pain; Cellular

Understanding gender differences in pain: Cellular therapies for animal pain. This project aims to relieve chronic pain in animals and lay the foundations for future human therapies, using molecular assays, cell technologies and immune/hormonal pain generators. Chronic pain affects females more than males. Establishing the fundamental mechanism in pain, the role of immune signalling and molecular mediators will enable true pain-modifying treatments that address pivotal triggers in both genders. This project will then use specially selected stem cells separately targeting arthritic male and female pain and demonstrate novel veterinary chronic pain treatments. Expected outcomes are more effective gender-targeted treatments of pain and the realisation of economic value of molecular assays and cell technologies.

了解疼痛的性别差异：动物疼痛的细胞疗法。该项目旨在缓解动物的慢性疼痛，并为未来的人类疗法奠定基础，使用分子测定，细胞技术和免疫/激素疼痛发生器。慢性疼痛对女性的影响大于男性。建立疼痛的基本机制，免疫信号传导和分子介质的作用将使真正的疼痛缓解治疗能够解决两种性别的关键触发因素。然后，该项目将使用专门选择的干细胞分别针对关节炎男性和女性疼痛，并展示新的兽医慢性疼痛治疗。预期成果是更有效的针对性别的疼痛治疗，以及实现分子测定和细胞技术的经济价值。