EAGER: Developing a Unified Framework for the Dynamics and Structure of Organisms, Cities and Companies

EAGER:为有机体、城市和公司的动态和结构开发统一框架

基本信息

  • 批准号:
    1838420
  • 负责人:
  • 金额:
    $ 30万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-01 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

The major thrust of this project is to develop a quantitative and predictive unified framework for understanding the coarse-grained structure and dynamics of biological and social systems across all scales from cells and multicellular organisms to ecosystems, cities and companies. Techniques from mathematics and physics such as network theory, field theory and non-linear dynamics, scaling and the renormalization group, as well as numerical simulations, will be used where appropriate but crucially and necessarily in convergent collaboration with theorists, experimentalists, and practitioners in the multiple fields with which the work overlaps. Developing a science of cities to complement traditional, more qualitative approaches is urgently required to address global sustainability. Can we maintain a vibrant, innovative society driven by ideas and wealth creation or are we destined to a planet of slums, conflict and devastation? The ever-increasing pace of life and increasingly rapid rate of change driven by positive feedback mechanisms in social networks induces serious stress across all aspects of life. Is this sustainable or are we headed for major disruptions to the socio-economic fabric? To address these issues a new conceptual framework is needed, encompassing a quantitative theory of cities, a Grand Unified Theory of Sustainability that integrates across the multiplicity of challenges we face.This is an ambitious program that transcends conventional disciplinary boundaries, ranging across the mathematical, physical, biological and social sciences, with potentially important implications for addressing societal issues such as aging, cancer, urbanization and global sustainability. The two main categories to be explored are i) a generic theory of aging, damage, sleep and repair; and (ii) developing a science of cities, urbanisation and global sustainability. Although the overall goal will be to explore the development of a potential unified framework for quantitative understanding of how these diverse, highly complex evolving systems can be understood from a parsimonious mathematically quantifiable set of underlying principles and concepts, this will be carried out in the context of focusing on several specific problems such as: how are lifetimes whose scale is years generated from microscopic molecular time scales associated with genes and respiratory enzymes? Why is the half-life of US publicly-traded companies about 10 years? Why, on average, do all companies and organisms stop growing and die but almost all cities keep growing and remain viable? Does the scaling of sleep times from babies to adults recapitulate how it scales from mice to elephants? Is there a maximum or optimum size of cities?This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该项目的主要目标是开发一个定量和预测性的统一框架,用于理解从细胞和多细胞生物到生态系统,城市和公司的所有尺度的生物和社会系统的粗粒度结构和动态。从数学和物理技术,如网络理论,场论和非线性动力学,缩放和重整化群,以及数值模拟,将在适当的情况下使用,但至关重要的是,必须在收敛合作与理论家,实验学家,和从业者在多个领域的工作重叠。迫切需要发展城市科学,以补充传统的、更注重质量的方法,以解决全球可持续性问题。我们能否保持一个由思想和财富创造驱动的充满活力和创新的社会,还是我们注定要成为一个充满贫民窟、冲突和破坏的星球?在社交网络的正反馈机制的推动下,生活节奏不断加快,变化速度也越来越快,这给生活的各个方面带来了严重的压力。这是可持续的,还是我们正在走向对社会经济结构的重大破坏?为了解决这些问题,需要一个新的概念框架,包括城市的定量理论,一个整合了我们面临的多种挑战的可持续发展的大统一理论。这是一个雄心勃勃的计划,超越了传统的学科界限,涉及数学,物理,生物和社会科学,对解决老龄化,癌症,城市化和全球可持续性。要探索的两个主要类别是:(i)衰老,损伤,睡眠和修复的一般理论;(ii)发展城市,城市化和全球可持续性的科学。虽然总的目标是探索建立一个潜在的统一框架,以便从数量上理解如何从一套简约的数学上可量化的基本原则和概念来理解这些多样化、高度复杂的演变系统,但这将在侧重于以下几个具体问题的背景下进行:以年为尺度的生命是如何从与基因和呼吸酶相关的微观分子时间尺度产生的?为什么美国上市公司的半衰期约为10年?为什么平均而言,所有的公司和有机体都停止增长并死亡,但几乎所有的城市都保持增长并保持活力?从婴儿到成年人的睡眠时间的比例是否可以概括从老鼠到大象的比例?是否存在城市的最大或最优规模?该奖项反映了NSF的法定使命,并被认为是值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估的支持。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development.
  • DOI:
    10.1126/sciadv.aba0398
  • 发表时间:
    2020-09
  • 期刊:
  • 影响因子:
    13.6
  • 作者:
    Cao J;Herman AB;West GB;Poe G;Savage VM
  • 通讯作者:
    Savage VM
Scaling of urban income inequality in the USA
  • DOI:
    10.1098/rsif.2021.0223
  • 发表时间:
    2021-08-04
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Mora, Elisa Heinrich;Heine, Cate;Kempes, Christopher P.
  • 通讯作者:
    Kempes, Christopher P.
The Scales That Limit: The Physical Boundaries of Evolution
  • DOI:
    10.3389/fevo.2019.00242
  • 发表时间:
    2019-08-07
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Kempes, Christopher P.;Koehl, M. A. R.;West, Geoffrey B.
  • 通讯作者:
    West, Geoffrey B.
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Geoffrey West其他文献

Comparing Teacher and Student Report of Behavioral Risk in Predicting Elementary Student Math Outcomes
比较教师和学生预测小学生数学成绩的行为风险报告
  • DOI:
    10.1177/1534508419885016
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    1.3
  • 作者:
    Nathaniel P. von der Embse;Andrew Jenkins;Geoffrey West;Katie Eklund;Stephen P. Kilgus;Myesha M. Morgan
  • 通讯作者:
    Myesha M. Morgan
Implications of race and ethnicity for child physical activity and social connections at summer care programs
种族和民族对夏季护理项目中儿童体育活动和社会联系的影响
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    T. Prochnow;M. Patterson;Logan Hartnell;Geoffrey West;M. R. Umstattd Meyer
  • 通讯作者:
    M. R. Umstattd Meyer

Geoffrey West的其他文献

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{{ truncateString('Geoffrey West', 18)}}的其他基金

EAGER: Innovation and Growth of Human Social Organizations from Cities to Corporations
EAGER:从城市到企业的人类社会组织的创新与成长
  • 批准号:
    1035225
  • 财政年份:
    2010
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
The Physical Foundations and Systems Biology of Aging; Santa Fe, New Mexico
衰老的物理基础和系统生物学;
  • 批准号:
    0946635
  • 财政年份:
    2009
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Research Experiences for Undergraduates Site at the Santa Fe Institute
圣达菲研究所本科生研究经历网站
  • 批准号:
    0851830
  • 财政年份:
    2009
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Universal Scaling Laws in Biology: Origins, Applications, Ramifications, and Extensions
生物学中的普遍尺度定律:起源、应用、后果和扩展
  • 批准号:
    0750037
  • 财政年份:
    2008
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant
A Broad Research Program in the Sciences of Complexity
复杂性科学的广泛研究计划
  • 批准号:
    0706174
  • 财政年份:
    2007
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant
Research Experiences for Undergraduate Interns at the Santa Fe Institute
圣达菲研究所本科生实习生的研究经历
  • 批准号:
    0353791
  • 财政年份:
    2004
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant
A Broad Research Program in the Sciences of Complexity
复杂性科学的广泛研究计划
  • 批准号:
    0200500
  • 财政年份:
    2002
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant
Universal Scaling Laws in Biology: Origins, Applications, and Ramifications
生物学中的普遍尺度定律:起源、应用和后果
  • 批准号:
    0202180
  • 财政年份:
    2002
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant
Universal Scaling Laws in Biology
生物学中的普遍尺度定律
  • 批准号:
    9873638
  • 财政年份:
    1998
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant

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