MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：获取 400 MHz 核磁共振 (NMR) 波谱仪

• 批准号: 1919501
• 负责人: Kevin Williams
• 金额: $ 30.45万
• 依托单位: Western Kentucky University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919501&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; Nuclear

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Kevin Williams from Western Kentucky University and colleagues Lester Pesterfield, Rui Zhang, Lawrence Hill and Yongming Deng have acquired a 400 MHz NMR spectrometer equipped with an automatic sampler. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as facilitating studies of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The NMR studies improve understanding of synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research. This broadly accessible instrumentation strengthens the regional NMR analytical infrastructure. Local high school students and teachers are participating in research activities. Training research students to operate a state-of-the-art NMR spectrometer is an integral part of institutional mission to perform student-centered, engaged research.The acquisition of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts exploration of the synthesis, reactivity, and biological activity of platinum(II) compounds that may be used as anticancer drugs and the development of methodologies for the synthesis of photocatalyzed alkynes reactions and biocompatible iron catalysts for carbene transfers. The NMR spectrometer is also used in studies that involve preparation of degradable polymers with antioxidant pendant groups and those using ionic liquid ligands for the synthesis of nanoparticle catalysts. In addition, it benefits the analysis and production of highly reactive metal-oxo species with molecular oxygen and visible light as oxidative catalysts. The spectrometer also serves researchers investigating hydrogen-deuterium exchange in cobalt(III) ammine complexes and correlating cobalt(III) chemical shifts with electronic transition energies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。来自西肯塔基州大学的Kevin威廉姆斯教授及其同事Lester Pesterfield、Rui Zhang、Lawrence Hill和Yongming Deng获得了一台配备自动采样器的400 MHz NMR光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及促进生物相关物种的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。NMR研究提高了对合成有机/无机化学，材料化学和生物化学的理解。该仪器是教学和研究的一个组成部分。这种广泛使用的仪器加强了区域核磁共振分析基础设施。当地高中学生和教师正在参加研究活动。培训研究学生操作最先进的NMR光谱仪是机构使命的一个组成部分，以执行以学生为中心的，从事研究。购买NMR光谱仪的目的是加强各级研究和教育。它特别影响探索的合成，反应性和生物活性的铂（II）化合物，可用作抗癌药物和开发的方法，用于合成光催化的炔反应和生物相容性铁催化剂的卡宾转移。NMR光谱仪还用于研究，包括制备具有抗氧化剂侧基的可降解聚合物，以及使用离子液体配体合成纳米颗粒催化剂。此外，它有利于分析和生产高活性的金属氧物种与分子氧和可见光作为氧化催化剂。该光谱仪还为研究钴氨络合物中氢氘交换的研究人员提供服务，并将钴（III）化学位移与电子跃迁能量相关联。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Kinetics of chromium(V)-oxo and chromium(IV)-oxo porphyrins: Reactivity and mechanism for sulfoxidation reactions.

• DOI: 10.2139/ssrn.4163383
• 发表时间: 2022-09
• 期刊: Journal of inorganic biochemistry
• 影响因子: 3.9
• 作者: Tristan Skipworth;Mardan Khashimov;Iyanu Ojo;Rui Zhang