MRI: Acquisition of a Liquid-Chromatograph Mass Spectrometer (LC-MS) for Research and Training at Grand Valley State University

MRI：为大谷州立大学的研究和培训采购液相色谱质谱仪 (LC-MS)

• 批准号: 1919817
• 负责人: Laura Hawk
• 金额: $ 14.38万
• 依托单位: Grand Valley State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919817&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatograph; Mass

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Professor Laura Hawk from Grand Valley State University and colleagues Shannon Biros, Andrew Lantz, Paul Cook and Dalila Kovacs are acquiring a compact a liquid-chromatograph mass-spectrometer (LCMS) having a single quadrupole mass analyzer. The mass spectrometer is equipped with a series of ionization sources such as electrospray ionization (ESI), an atmospheric pressure chemical ionization/atmospheric solid analysis probe (APCI/ASAP), as well as a thin layer chromatography (TLC) plate reader. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components are heated and flow into a mass spectrometer where they are ionized. The ions' masses are measured very accurately. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. The various ionization sources provide added flexibility with regard to the types of samples that are analyzed. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. This instrument acquisition supports many female and underrepresented investigators. It also provides training opportunities to undergraduate students, many of whom are first-generation students. The instrument gives students experience using vital instrumentation that they carry with them into their careers. The award of this mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts studies of beneficial amyloids which are aggregates of proteins that become folded into various shapes. The instrument is used to evaluate the role of intrinsically-disordered regions in protein structure and function as well as the development of ligands for the separation of critical elements such as rare earth (f) elements. The mass spectrometer is employed in studies of enzymes that inactivate antibiotics in bacteria and for the development of organic flow cell electrolytes for batteries. The instrument also serves researchers investigating the conversion of biomass into commodity chemicals and those looking for targets of the protein focal adhesion kinase.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。来自大峡谷州立大学的Laura Hawk教授及其同事Shannon Biros、Andrew Lantz、Paul Cook和Dalila Kovacs正在购买一台紧凑型液相色谱质谱仪（LCMS），该质谱仪具有一个四极杆质量分析器。质谱仪配备了一系列电离源，如电喷雾电离（ESI）、大气压化学电离/大气压固体分析探针（APCI/ASAP）以及薄层色谱（TLC）酶标仪。一般来说，质谱（MS）是用于识别和表征复杂样品中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中，成分被加热并流入质谱仪，在那里它们被电离。 离子的质量被非常精确地测量。这种高灵敏度的技术可以研究复杂混合物中的分子结构。带有液相色谱仪的仪器可以在化合物到达质谱仪之前将其分离。各种电离源提供了关于被分析的样品类型的额外灵活性。此次收购加强了大学和地区的研究基础设施。该工具通过利用这一现代分析技术使不同群体的学生参与研究和研究培训，扩大了参与。 这一仪器采购支持了许多女性和代表性不足的调查人员。它还为本科生提供培训机会，其中许多是第一代学生。该仪器为学生提供使用重要仪器的经验，这些仪器将与他们一起进入职业生涯。授予这一质谱仪的目的是加强各级的研究和教育。它特别影响了有益的淀粉样蛋白的研究，淀粉样蛋白是折叠成各种形状的蛋白质聚集体。该仪器用于评估蛋白质结构和功能中内在无序区域的作用，以及用于分离稀土（f）元素等关键元素的配体的开发。 质谱仪用于研究细菌中的抗生素酶，并用于开发电池的有机流动电池电解质。该仪器还为研究生物质转化为商品化学品的研究人员以及寻找蛋白质粘着斑激酶靶点的研究人员提供服务。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Two Beta-Phosphorylamide Compounds as Ligands for Sm3+, Eu3+, and Tb3+: X-ray Crystallography and Luminescence Properties

两种 β-磷酰胺化合物作为 Sm3 、 Eu3 和 Tb3 的配体：X 射线晶体学和发光性质

• DOI: 10.3390/molecules25132971
• 发表时间: 2020
• 期刊: Molecules
• 影响因子: 4.6
• 作者: Lear, Alan R.;Lenters, Jonah;Patterson, Michael G.;Staples, Richard J.;Werner, Eric J.;Biros, Shannon M.
• 通讯作者: Biros, Shannon M.

Synthesis and crystallographic characterization of N-allyl-N-benzyl-4-methylbenzenesulfonamide

N-烯丙基-N-苄基-4-甲基苯磺酰胺的合成及晶体学表征

• DOI: 10.5155/eurjchem.11.3.245-249.2017
• 发表时间: 2020
• 期刊: European Journal of Chemistry
• 作者: Stenfors, Brock Anton;Ngassa, Felix Nyuangem
• 通讯作者: Ngassa, Felix Nyuangem

Crystal structure of 4-methyl- N -propylbenzenesulfonamide

4-甲基-N-丙基苯磺酰胺的晶体结构

• DOI: 10.1107/s2056989020007756
• 发表时间: 2020
• 期刊: Acta Crystallographica Section E Crystallographic Communications
• 作者: Stenfors, Brock A.;Collins, Rachel C.;Duran, Jonah R.;Staples, Richard J.;Biros, Shannon M.;Ngassa, Felix N.
• 通讯作者: Ngassa, Felix N.

Syntheses and crystal structures of the anhydride 4-oxatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-ene-3,5-dione and the related imide 4-(4-bromophenyl)-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-ene-3,5-dione

酸酐 4-oxatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-ene-3,5-dione 和相关酰亚胺 4-(4-bromoryl)-4-azatetracyclo[ 的合成和晶体结构]

• DOI: 10.1107/s2056989020009512
• 发表时间: 2020
• 期刊: Acta Crystallographica Section E Crystallographic Communications
• 作者: Hulsman, Andrew;Lorenzana, Isabel;Schultz, Theodore;Squires, Breezy;Stenfors, Brock A.;Tolonen, Mason;Staples, Richard J.;Biros, Shannon M.;Winchester, William R.
• 通讯作者: Winchester, William R.

Crystal structure of N , N -diisopropyl-4-methylbenzenesulfonamide

N,N-二异丙基-4-甲基苯磺酰胺的晶体结构

• DOI: 10.1107/s2056989020007185
• 发表时间: 2020
• 期刊: Acta Crystallographica Section E Crystallographic Communications
• 作者: Stenfors, Brock A.;Staples, Richard J.;Biros, Shannon M.;Ngassa, Felix N.
• 通讯作者: Ngassa, Felix N.