MRI: Acquisition of a Liquid Chromatography-Mass Spectrometry (LC-MS) System to Enable Research and Enhance Undergraduate Education at Western Washington University

MRI：采购液相色谱-质谱 (LC-MS) 系统以支持西华盛顿大学的研究并加强本科教育

• 批准号: 1920340
• 负责人: John Antos
• 金额: $ 49.99万
• 依托单位: Western Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1920340&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatography; Mass

An award is made to Western Washington University (WWU) for the acquisition of a state-of-the-art liquid chromatography-mass spectrometry (LC-MS) system. This instrument, which will be housed and maintained within a centralized instrument facility, will provide a core institutional resource for a broad range of research and teaching activities at WWU's main campus and Shannon Point Marine Center (SPMC). As a primarily undergraduate institution, WWU is committed to providing the highest-level of classroom instruction, while also offering authentic research experiences for undergraduate and masters-level graduate students. The LC-MS will directly support this mission. First, it will be incorporated into multiple courses in the STEM curriculum, providing meaningful exposure to mass spectrometry for hundreds of undergraduates every year. The LC-MS will also become a key component of a collaborative project involving laboratory courses at WWU and a local community college. Finally, outside of the classroom, students involved in faculty led research will be afforded new opportunities for hands-on training in modern mass spectrometry techniques, providing them with a skill set that will be valuable when seeking employment in the scientific workforce or for pursuing advanced graduate studies.In addition to impacts on teaching and student training, the LC-MS will be transformative for numerous research programs at WWU and SPMC. Mass spectrometry is a foundational technique in the biological and chemical sciences, and is often the preferred method for confirming molecular structure or for measuring the abundance of specific compounds in complex biological and environmental samples. Examples of research efforts that will be enabled by the LC-MS include the engineering of proteins with unique biological properties, structural studies of proteins involved in blood coagulation or the maintenance of cell shape, identification and quantitation of signaling molecules and other natural products that are involved in ecological interactions and responses to environmental change, fundamental investigations of protein and gene regulation systems, and the synthesis of novel compounds. In all cases, the results of these studies will be disseminated to the broader scientific community at appropriate scientific conferences and through peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

西华盛顿大学（WWU）因收购最先进的液相色谱-质谱（LC-MS）系统而获奖。该仪器将被安置在一个集中的仪器设施内并进行维护，将为WWU主校区和香农角海洋中心（SPMC）的广泛研究和教学活动提供核心机构资源。作为一个主要的本科院校，WWU致力于提供最高水平的课堂教学，同时也为本科和硕士研究生提供真实的研究经验。LC-MS将直接支持这一使命。首先，它将被纳入STEM课程的多门课程中，每年为数百名本科生提供有意义的质谱接触。LC-MS也将成为一个合作项目的关键组成部分，该项目涉及WWU和当地社区学院的实验室课程。最后，在课堂之外，参与教师领导的研究的学生将获得现代质谱技术实践培训的新机会，为他们提供在科学劳动力中寻找就业机会或追求高级研究生学习时有价值的技能。除了对教学和学生培训的影响外，LC-MS将为WWU和SPMC的许多研究项目带来变革。质谱是生物和化学科学中的基础技术，通常是确认分子结构或测量复杂生物和环境样品中特定化合物丰度的首选方法。将通过LC-MS实现的研究工作的例子包括具有独特生物学特性的蛋白质的工程化，参与血液凝固或细胞形状维持的蛋白质的结构研究，信号分子和参与生态相互作用和对环境变化的响应的其他天然产物的鉴定和定量，蛋白质和基因调控系统的基础研究，以及新化合物的合成。在所有情况下，这些研究的结果将在适当的科学会议上和通过同行评审的出版物传播给更广泛的科学界。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。