MRI: Acquisition of a Dynamic Nuclear Polarization (DNP) Nuclear Magnetic Resonance (NMR) System

MRI：动态核极化 (DNP) 核磁共振 (NMR) 系统的采集

• 批准号: 2018756
• 负责人: Lauren Marbella
• 金额: $ 100万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018756&HistoricalAwards=false
• 关键词: MRI; Acquisition; Dynamic; Nuclear; Polarization

Nontechnical Description:This Major Research Instrumentation (MRI) award is to acquire a klystron microwave source and a magnet for dynamic nuclear polarization nuclear magnetic resonance (DNP NMR) spectroscopy together with an existing 400 MHz NMR console. DNP uses microwaves to increase detection sensitivity by up to two orders of magnitude, making materials characterization that was previously intractable via a traditional NMR (spectral acquisition of months) now accessible with a collection time of hours. A broad user base with diverse, interdisciplinary research activities on energy storage, heterogeneous catalysis, biomaterials, and NMR methods development benefits from the instrument acquisition and is bolstered by partnerships with industry in the greater New York/New Jersey area. Practical training in DNP NMR in both undergraduate and graduate coursework at Columbia as well as bridge programs between Columbia and Barnard (an all women liberal arts Columbia affiliate) are integrated with research to increase the participation of underrepresented groups in the training infrastructure.Technical Description:DNP NMR spectroscopy has revolutionized the characterization of low sensitivity elements and surface species, allowing structural assignment at the molecular level for systems of fundamental or commercial interest. The 263 GHz klystron/400 MHz sweepable magnet offers i) an appropriate mid-field strength to study materials with large anisotropies (e.g. nanoparticles and clusters), ii) multinuclear NMR capabilities that enable the study of challenging low gamma/quadrupolar NMR nuclei in technologically relevant materials (e.g. batteries and catalysts), and iii) the development of new designer radicals for DNP. The klystron microwave source fits within the space constraints and minimizes instrument maintenance. The instrument acquisition enables and accelerates the characterization of a wide range of inorganic and biomaterials, with an emphasis on sustainability, as well as educational activities.This Major Research Instrumentation award is jointly funded by the Division of Materials Research (DMR) and Division of Chemistry (CHE).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术描述：该主要研究仪器（MRI）奖将获得一个速调管微波源和一个用于动态核极化核磁共振（DNP NMR）光谱学的磁体，以及一个现有的400 MHz核磁共振控制台。DNP使用微波将检测灵敏度提高了两个数量级，使得以前难以通过传统的核磁共振（数月的光谱采集）进行材料表征，现在只需几个小时的收集时间就可以完成。在能源存储、多相催化、生物材料和核磁共振方法开发方面，广泛的跨学科研究活动的用户基础受益于仪器收购，并通过与大纽约/新泽西地区的行业合作伙伴关系得到支持。哥伦比亚大学本科和研究生课程中DNP NMR的实践培训，以及哥伦比亚大学和巴纳德学院（哥伦比亚大学的全女性文科附属机构）之间的桥梁项目，都与研究相结合，以增加代表性不足的群体在培训基础设施中的参与。技术描述：DNP核磁共振光谱已经彻底改变了低灵敏度元素和表面物质的表征，允许在分子水平上对基础或商业利益的系统进行结构分配。263 GHz速调管/400 MHz可扫磁磁体提供i)适当的中场强度来研究具有大各向异性的材料（例如纳米颗粒和簇），ii)多核核磁共振能力，使研究具有挑战性的低伽马/四极性核磁共振核在技术相关材料（例如电池和催化剂）中，以及iii) DNP的新设计自由基的开发。速调管微波源符合空间限制，并最大限度地减少仪器维护。仪器的获取能够并加速了对各种无机和生物材料的表征，重点是可持续性以及教育活动。该重大研究仪器奖由材料研究部（DMR）和化学部（CHE）共同资助。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。