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MRI: Acquisition of a Cryoprobe Equipped Nuclear Magnetic Resonance Spectrometer for Studying Macromolecules, Bioactive Isolates, and Dynamic Processes

MRI：购买配备冷冻探针的核磁共振波谱仪，用于研究大分子、生物活性分离物和动态过程

基本信息

批准号：
1919906
负责人：
Paul Rupar
金额：
$ 53.29万
依托单位：
University of Alabama Tuscaloosa
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919906&HistoricalAwards=false
关键词：
MRI Acquisition Cryoprobe Equipped Nuclear

项目摘要

This award is jointly funded by the Chemical Research Instrumentation (CRIF) program, the Established Program to Stimulate Competitive Research (EPSCoR), and the Major Research Instrumentation (MRI) program. Professor Paul Rupar from the University of Alabama Tuscaloosa and colleagues Elizabeth Papish, Jason Bara, Marco Bonizzoni and Lukasz Ciesla are acquiring a 500 MHz NMR spectrometer equipped with a cryoprobe. Nuclear magnetic resonance (NMR) spectrometers measure the interaction of radio waves with a sample's atomic nuclei in the presence of a strong magnetic field. The information provided by NMR spectrometers allows researchers to identify unknown substances, determine the structure of molecules, macromolecules, and biomolecules, and monitor reaction dynamics in solution. Because of its versatility, ease of use, and non-destructive nature, NMR spectroscopy supports much of modern chemical-based research and is critical to the fields of organic chemistry, inorganic chemistry, biology, chemical engineering, biochemistry and materials science. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes. The instrument is also used to train undergraduate and graduate students in the use of this powerful tool. The spectrometer is available for use by researchers at other institutions including Tuskegee University and Samford University.The award is aimed at enhancing research and education at all levels. Many research projects are progress and aided by this spectrometer. One project conducts structural studies of polymers used in chemical sensors, three-dimensional (3D) printing and in non-viral gene-transfection. Studies of the reduction of carbon dioxide catalyzed by transition metals are also being carried out. Work in another research group focuses on the bioinorganic chemistry of chromium, a potent mutagen and carcinogen when present as chromate. Routes to the development of pure cellulose-based plastics using current 3D printing technology are under study. Carbon dioxide reduction using ruthenium complexes as catalysts is also being investigated including efforts to eliminate the photosensitizer in the reduction process.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由化学研究仪器（CRIF）计划，刺激竞争性研究的既定计划（EPSCoR）和主要研究仪器（MRI）计划共同资助。来自亚拉巴马塔斯卡卢萨大学的Paul Rupar教授及其同事Elizabeth Papish、Jason Bara、Marco Bonizzoni和Lukasz Ciesla正在购买一台配备冷冻探针的500 MHz NMR光谱仪。核磁共振（NMR）光谱仪测量在强磁场存在下无线电波与样品原子核的相互作用。NMR光谱仪提供的信息使研究人员能够识别未知物质，确定分子，大分子和生物分子的结构，并监测溶液中的反应动力学。由于其多功能性，易用性和非破坏性，NMR光谱支持许多现代化学研究，对有机化学，无机化学，生物学，化学工程，生物化学和材料科学领域至关重要。相对于标准NMR探针，低温探针提供了灵敏度的显著增加。该仪器还用于培训本科生和研究生使用这一强大的工具。该光谱仪可供包括塔斯基吉大学和桑福德大学在内的其他机构的研究人员使用。该奖项旨在加强各级的研究和教育。许多研究项目的进展和帮助，这台光谱仪。其中一个项目对用于化学传感器、三维（3D）打印和非病毒基因转染的聚合物进行结构研究。目前还在进行过渡金属催化还原二氧化碳的研究。另一个研究小组的工作集中在铬的生物无机化学上，当以铬酸盐存在时，铬是一种强效的诱变剂和致癌物。目前正在研究使用当前3D打印技术开发纯纤维素塑料的途径。此外，还在研究使用钌络合物作为催化剂来减少二氧化碳，包括在减少过程中消除光敏剂的努力。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。