Fabrication and Scalable Production of Nanobottles

纳米瓶的制造和规模化生产

基本信息

批准号：
2137669
负责人：
Younan Xia
金额：
$ 39.15万
依托单位：
Georgia Tech Research Corporation
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-01 至 2024-11-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2137669&HistoricalAwards=false
关键词：
Fabrication Scalable Production Nanobottles

项目摘要

This grant supports research that will create new knowledge related to the manufacturing of nanobottles made of diverse materials, together with controllable dimensions, shapes, and opening sizes. Macroscopic bottles are ubiquitous in our everyday life. The unique design of a bottle offers immediate advantages in terms of easiness and convenience for packaging, storage, and transportation. While there are mature technologies for manufacturing macroscopic bottles made of glasses, metals, and polymers on an industrial scale, it is impossible to apply the same technology to the fabrication of nanoscopic (or even microscopic) bottles due to lack of tools capable of handling such minuscule structures. This grant supports fundamental research to provide needed knowledge for the development of a precise and robust method for fabricating nanobottles and the results from this research will benefit the U.S. economy and society. The nanobottles are increasingly preferred for applications involving encapsulation, controlled release, and drug delivery, with immediate impacts on biomedicine and healthcare. They are also expected to enable the encapsulation and controlled release of chemical substances essential to environmental remediation and agriculture. The multi-disciplinary and collaborative nature will help broaden participation of underrepresented groups in research, offering a vehicle to enrich the education and training experiences of participating students. The results from this research will be further adapted to enhance classroom teaching, including the development of demonstrations, e.g. animations and experiments, related to the key concepts of materials science and biomedical engineering.This research will focus on nanobottles in the form of colloidal hollow particles of 50−500 nm in diameter, together with a single hole in the otherwise impermeable wall. By coating the surface of a colloidal template with a different material and then selectively etching away the template, one can obtain a hollow particle with its size and shape precisely defined by the template. This method has been successfully applied to a variety of materials, but there is no reliable strategy for generating a well-controlled hole in the wall of the hollow particle. This research is to fill the knowledge gap on the mechanism(s) of hole creation by swelling the shell-coated template with a solvent. When the swelling-induced pressure reaches a critical level, it will spontaneously poke a hole in the shell to release the pressure and allow the swollen template to escape through the opening. This fabrication method can be applied to essentially all types of materials, including ceramics, metals, and polymers, as long as they can be coated on the colloidal templates as uniform shells. Both the coating and swelling processes will be experimentally investigated and theoretically modeled to establish a mechanistic understanding and insightful guidance necessary for the future manufacturing of nanobottles. In a proof-of-concept demonstration, the nanobottles will be evaluated for the encapsulation and then controlled release of a therapeutic agent for the eradication of cancer cells.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项赠款支持研究，将创造与潜水员材料制成的纳米伯特的制造以及受控尺寸，形状和开放尺寸有关的新知识。宏观瓶在我们的日常生活中无处不在。瓶子的独特设计在包装，存储和运输方面的便利性和便利性方面具有立即的优势。尽管有成熟的技术，可以在工业尺度上制造由玻璃，金属和聚合物制成的宏观瓶，但由于缺乏能够处理此类微度结构的工具，因此不可能将相同的技术应用于纳米镜（甚至显微镜）瓶的制造上。这项赠款支持基本研究，以提供所需的知识，以开发一种制造纳米骨的精确和健壮方法，而这项研究的结果将使美国的经济和社会受益。对于涉及封装，受控释放和药物输送的应用，纳米骨质对生物医学和医疗保健产生了直接影响。他们还有望使环境修复和农业必不可少的化学物质的封装和受控释放。多学科和协作性质将有助于扩大代表性不足的小组参与研究的参与，从而提供丰富参与学生的教育和培训经验的工具。这项研究的结果将进一步适应增强课堂教学，包括示范的发展，例如动画和实验与材料科学和生物医学工程的关键概念有关。这项研究将重点关注直径为50-500 nm的胶体空心颗粒的形式，并在不可渗透的壁中进行单个孔。通过将胶体模板的表面涂上不同的材料，然后选择性地蚀刻模板，可以获得其大小和形状由模板精确定义的空心粒子。该方法已成功地应用于各种材料，但是没有可靠的策略可以在空心颗粒的壁上产生一个良好的控制孔。这项研究是通过用解决方案膨胀壳涂层模板来填补创建孔创造机制的知识差距。当肿胀诱导的压力达到临界水平时，它将在壳上赞助一个孔，以释放压力并允许肿胀的模板通过开口逸出。只要可以将这种制造方法用于所有类型的材料，包括陶瓷，金属和聚合物，只要它们可以像均匀的壳上涂在胶体模板上一样。涂层和肿胀过程都将进行实验研究和理论上的建模，以建立机械理解和有见地的指导，这是对纳米骨架的未来制造所必需的。在概念验证的演示中，将评估纳米机器人的封装，然后控制释放治疗剂以消除癌症细胞。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准来评估，被认为是珍贵的支持。