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From muscle fibre to tissue - experiment, modelling and simulation at micro, meso and makro scale

从肌肉纤维到组织 - 微观、中观和宏观尺度的实验、建模和模拟

基本信息

批准号：
258667461
负责人：
Professor Dr.-Ing. Markus Böl
金额：
--
依托单位：
Institut für Mikrotechnik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2022-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/258667461?language=en
关键词：
muscle fibre tissue experiment modelling

项目摘要

The present project deals with the analysis of complex deformation states of skeletal muscle tissue whose results will be integrated in a numerical multi-scale modelling approach. The essential aim within the project is the determination of the mechanical behaviour of the extracellular matrix (ECM) and consequently the prediction of changes based on quantitative and/or structural changes of the ECM. This knowledge, however, is of high medical as well as socioeconomical importance but rooted on previous analytical methods it could not be obtained. In order to advance research on this field, the present project combines two areas of expertise: microsystems technology and solid mechanics. This unique combination presents a completely new and innovative approach and enables the development of new methods in order to analyse skeletal muscle tissue from the experimental as well as numerical point of view.Therefore, this project provides extensive experimental analyses on different size scales. In a first step we apply at micro scale (10-90 µm) axial tension as well as axial/transversal compression experiments on single muscle fibres and muscle fibres segments, respectively. Further, at meso scale (0,1-1 mm), we focus on compression and shear-compression tests applied on cubes excised from muscle fascicles. Finally, cubes resected from muscle tissue will be tested at macro scale (1-24 mm).In order to perform such experiments special setups at micro and meso scale need to be developed. Their main components will be micro technological parallel grippers. In doing so, single muscle fibres or cubes resected from fascicles by means of ultra-short-pulse laser can be loaded and forces, displacements and deformations can be measured. Experiments at macro scale will be accomplished using well-known experimental methods.Based on these multi-scale experiments and by means of the inverse finite element method we establish a three-step identification process that allows to determinate the mechanical behaviour of ECM. Finally, rooted on these findings a multi-scale modelling approach and its validation is scheduled.

本项目涉及骨骼肌组织复杂变形状态的分析，其结果将集成在数值多尺度建模方法中。该项目的基本目标是确定细胞外基质（ECM）的机械行为，从而预测基于ECM数量和/或结构变化的变化。然而，这种知识具有很高的医学和社会经济重要性，但基于以前的分析方法是无法获得的。为了推进这一领域的研究，本项目结合了两个专业领域：微系统技术和固体力学。这种独特的组合提出了一种全新的创新方法，并使从实验和数值角度分析骨骼肌组织的新方法得以发展。因此，本项目在不同的尺度上进行了广泛的实验分析。在第一步中，我们分别对单个肌肉纤维和肌肉纤维段进行了微尺度（10-90 μ m）轴向拉伸和轴向/横向压缩实验。此外，在中尺度（0.1 -1毫米），我们重点研究了从肌肉束中切除的立方体的压缩和剪切压缩试验。最后，从肌肉组织中切除的立方体将在宏观尺度（1-24毫米）上进行测试。为了进行这样的实验，需要在微观和中观尺度上开发特殊的装置。它们的主要组成部分将是微型技术平行夹持器。在这样做的过程中，可以通过超短脉冲激光从肌束中切除单个肌肉纤维或立方体，并可以测量力，位移和变形。宏观尺度的实验将使用众所周知的实验方法来完成。基于这些多尺度实验，并通过逆有限元方法，我们建立了一个三步识别过程，可以确定ECM的力学行为。最后，基于这些发现，多尺度建模方法及其验证是预定的。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Micro-Gripper: A new concept for a monolithic single-cell manipulation device

DOI：
10.1016/j.sna.2015.10.024
发表时间：
2015-12-01
期刊：
SENSORS AND ACTUATORS A-PHYSICAL
影响因子：
4.6
作者：
Garces-Schroeder, Mayra;Leester-Schaedel, Monika;Dietzel, Andreas
通讯作者：
Dietzel, Andreas

Shape Memory Alloy Actuators for Silicon Microgrippers

DOI：
10.1109/jmems.2019.2936288
发表时间：
2019-10-01
期刊：
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
影响因子：
2.7
作者：
Garces-Schroeder, Mayra;Zimmermann, Tom;Dietzel, Andreas
通讯作者：
Dietzel, Andreas

Characterization of skeletal muscle passive mechanical properties by novel micro-force sensor and tissue micro-dissection by femtosecond laser ablation

DOI：
10.1016/j.mee.2018.01.024
发表时间：
2018-05
期刊：
Microelectronic Engineering
影响因子：
2.3
作者：
Mayra Garcés-Schröder;D. Metz;Lars Hecht;Rahul Iyer;M. Leester-Schädel;M. Böl;A. Dietzel
通讯作者：
Mayra Garcés-Schröder;D. Metz;Lars Hecht;Rahul Iyer;M. Leester-Schädel;M. Böl;A. Dietzel

Direct measurement of the direction-dependent mechanical behaviour of skeletal muscle extracellular matrix.

直接测量骨骼肌细胞外基质的方向依赖性机械行为