Surface engineering of carrier-free drug nanoparticle toward highly efficient anticancer drug delivery

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Surface modification strategies were carefully monitored to achieve drug nanoparticles with enhanced drug delivery efficiency (Chem. Lett. 2021, 50, 1555-1558; Mol. Crys. Liq. Crys., in press 2022). For the preparation of liposomal membrane modified drug nanoparticles, the coating on the drug nanoparticle surface was achieved by the sequential extrusion of membrane vesicle with the SN-38 drug nanoparticles model system. The modified drug nanoparticles were obtained in a slightly larger size, with narrow size distribution as confirmed by DLS. The liposomal layer on the nanoparticle’s surface was successfully confirmed by fluorescence and SEM images. In addition to the enhanced dispersion stability in the physiological environment, we have also shown that the liposomal membrane layer can be further modified to provide drug nanoparticles with specific cancer targeting and fluorescence imaging capability. The optimized protocol will be employed for the modification of drug nanoparticles with the liposomal membrane derived from natural sources such as red blood cells, white blood cells, and cancer cells.