Role and function of taxilin in the complex formation of molecules related to intracellular signal transduction in a regenerating liver

在这个项目中，我们试图揭示与囊泡运输相关的分子&紫杉素调节与细胞内信号转导相关的分子在细胞内传递的机制。我们得到了以下结果：1)&#61537；-紫杉林在肝部分切除后的再生肝中过表达。2)&#61537；-紫杉林定位于Hela细胞内一些与微管相连的细胞器上。3)&#61537；-紫杉林与分选Nexin 4相互作用，并参与转铁蛋白受体的循环。在这些结果的基础上，提出了紫杉素可能参与了与细胞内信号转导相关的分子的复合体的形成，这些分子通过调节细胞内的小泡运输而与转铁蛋白受体相连。

In this project, we attempted to reveal the mechanism by which -taxilin, a molecule related to vesicle transport, regulates intracellular delivery of molecules related to intracellular signal transduction. We obtained the following results: 1) -Taxilin was overexpressed in the regenerating liver after partial hepatectomy. 2) -Taxilin was localized on some intracellular organelles connected to the microtubule in Hela cells. 3) -Taxilin interacted with sorting nexin 4 and was implicated in the recycling of transferrin receptor. On the basis of these results, the possibility was raised that -taxilin might be involved in the complex formation of molecules related to intracellular signal transduction that are connected with transferrin receptor through regulating intracellular vesicle transport.