Examination of signaling pathway specific to oral mucosa wound healing.- Difference between oral mucosa and epidermis -

检查口腔粘膜伤口愈合特有的信号通路。-口腔粘膜和表皮的区别-

• 批准号: 23659857
• 负责人: MAEDA Takeyasu
• 金额: $ 2.33万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659857/
• 关键词: ケラチノサイト; PI3K/Aktシグナリング; PTEN; 創傷治癒モデル; 細胞運動能; 口腔粘膜; 皮膚

Oral mucosa heals faster than does skin, and scar formation during the wound healing in oral mucosa is also less than that in skin. We attempted to explore these differences between oral keratinocytes and epidermal keratinocytes in vitro by intrinsic cellular, biological characteristics. PI3kinase signaling pathway was activated by using a pharmacological means. Using a scratch assay (in vitro wound healing assay), cell motility and protein expressions related to PI3kinase were examined. Those reagents used in this study did not induce any significant differences.

口腔粘膜愈合快于皮肤，且愈合过程中瘢痕形成少。我们试图通过体外培养的口腔角朊细胞和表皮角朊细胞内在的细胞生物学特性来探讨这些差异。通过药理学手段激活PI3激酶信号通路。使用划痕试验（体外伤口愈合试验），检测细胞运动性和与PI3激酶相关的蛋白表达。本研究中使用的试剂未引起任何显著差异。

项目成果

Intraoral grafting of tissue-engineered human oral mucosa.

• DOI: 10.11607/jomi.te11
• 发表时间: 2013-09
• 期刊: The International journal of oral & maxillofacial implants
• 作者: Izumi K;Neiva RF;Feinberg SE
• 通讯作者: Feinberg SE