Roles of new ion channel involved in the regeneration/development of the periodontal Ruffini endings

本研究基于牙周膜和三叉神经节酸敏感离子通道-3（ASIC 3）表达模式的变化，研究了牙周Ruffini末端（一种重要的机械受体）的再生过程。从神经损伤模型（切除一侧的下牙槽神经）获得的结果表明，这种分子不直接参与牙周Ruffini末梢的轴突再生，而是参与神经元-胶质细胞相互作用，如控制三叉神经节中的神经元活性。

This study examined the regeneration process of the periodontal Ruffini ending, an essential mecahnoreceptor, based on the changes in the expression pattern of acid-sensing ion channel-3 (ASIC3) at the periodontal ligament and trigeminal ganglion. The findings obtained from the nerve injury model (resection of the inferior alveoar nerve at one side) indicate that this molecule is not direcly involved in the axonal regeneration of the periodontal Ruffini endings but rather in neuron-glial interactions such as control of neuronal activity in the trigeminal ganglion.