Pathological study of AA amyloidosis in vaccinated white hens and

在蛋鸡群中爆发全身性淀粉样变性是由多次接种油乳化菌引起的反复炎症刺激引起的。在某大型家禽养殖场接种疫苗的生长鸡中发现了致死性AA淀粉样变暴发。在死鸡熔融后检查中观察到淀粉样蛋白沉积，提示接种肠炎沙门氏菌（SE）可能是AA淀粉样变发生的潜在风险。为了确定鸡AA淀粉样变在白母鸡中的传播，我们通过静脉注射或口服鸡AA原纤维诱导接种鸡实验性AA淀粉样变。在注射SE和经静脉和口服接种鸡AA原纤维的鸡中观察到淀粉样蛋白沉积。上述结果提示，鸡AA淀粉样变可通过接种引起，并可能在种间传播。

Outbreaks of systemic amyloidosis in flocks of layers are known to be induced by repeated inflammatory stimulation with multiple vaccinations with oil-emulsified bacterins. Outbreaks of fatal AA amyloidosis were observed in vaccinated growing chickens in a large scale poultry farm. Amyloid deposits were observed in postmolten examination of dead hens, suggesting that vaccinations with Salmonella Enteritidis (SE) would be considered as a potential risk for the development of AA amyloidosis. To determine the transmission of chicken AA amyloidosis among white hens, we induced experimental AA amyloidosis in vaccinated chickens by intravenous or oral administration of chicken AA fibrils. Amyloid deposits were observed in chickens ingected with SE and inouculated with chicken AA fibrils intravenously and orally. These results suggest that chicken AA amyloidosis can be induced by vaccinations, and may be transmitted among species.