Pathological study of AA amyloidosis in vaccinated white hens and

免疫白母鸡AA淀粉样变性的病理学研究

• 批准号: 24658254
• 负责人: ISHIGURO Naotaka
• 金额: $ 2.58万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24658254/
• 关键词: アミロイド; ニワトリ; ワクチン; 伝達; サルモネラ; 伝播

Outbreaks of systemic amyloidosis in flocks of layers are known to be induced by repeated inflammatory stimulation with multiple vaccinations with oil-emulsified bacterins. Outbreaks of fatal AA amyloidosis were observed in vaccinated growing chickens in a large scale poultry farm. Amyloid deposits were observed in postmolten examination of dead hens, suggesting that vaccinations with Salmonella Enteritidis (SE) would be considered as a potential risk for the development of AA amyloidosis. To determine the transmission of chicken AA amyloidosis among white hens, we induced experimental AA amyloidosis in vaccinated chickens by intravenous or oral administration of chicken AA fibrils. Amyloid deposits were observed in chickens ingected with SE and inouculated with chicken AA fibrils intravenously and orally. These results suggest that chicken AA amyloidosis can be induced by vaccinations, and may be transmitted among species.

已知蛋鸡群中系统性淀粉样变性的爆发是由多次接种油乳化的白蛋白引起的反复炎症刺激引起的。在一个大型家禽养殖场的接种生长鸡中观察到致命性AA淀粉样变性的爆发。在对死母鸡的熔化后检查中观察到淀粉样沉积物，这表明肠道沙门氏菌（SE）疫苗接种被认为是AA淀粉样变性发展的潜在风险。为了确定鸡AA淀粉样变性在白色母鸡中的传播，我们通过静脉内或口服给予鸡AA原纤维在接种疫苗的鸡中诱导实验性AA淀粉样变性。静脉和口服注射SE和鸡AA原纤维的鸡中观察到淀粉样蛋白沉积。这些结果表明，鸡AA淀粉样变性可以通过疫苗接种诱导，并可能在种间传播。

项目成果

ニワトリを用いた実験的AAアミロイドーシスの誘発

鸡实验性 AA 淀粉样变性的诱导

• 发表时间: 2012
• 作者: 村上智亮;猪島康雄;柳井徳磨;御領政信;石黒直隆
• 通讯作者: 石黒直隆

AA amyloidosis in vaccinated growing chickens

接种疫苗的生长鸡中的 AA 淀粉样变性

• DOI: 10.1016/j.jcpa.2013.02.002
• 发表时间: 2013
• 期刊: Journal of Comparative Pathology
• 影响因子: 0.8
• 作者: Murakami T;Inoshima Y;Sakamoto E;Fukushi H;Sakai H;Yanai T;Ishiguro N.
• 通讯作者: Ishiguro N.

実験的AAアミロイドーシスの伝播

实验性 AA 淀粉样变性的传播

• 发表时间: 2012
• 作者: 村上智亮;猪島康雄;石黒直隆
• 通讯作者: 石黒直隆

育成鶏に認められたＡＡアミロイドーシスの病理学的特徴

饲养鸡AA淀粉样变性的病理特征观察

• 发表时间: 2012
• 作者: 村上智亮;猪島康雄;酒井洋樹;福士秀人;石黒直隆;柳井徳磨
• 通讯作者: 柳井徳磨

Potential induction of vaccine-associated amyloid A amyloidosis in white young hens.

在白色幼母鸡中可能诱导疫苗相关的淀粉样蛋白 A 淀粉样变性。

• 发表时间: 2012
• 作者: Tomoaki Murakami;Yasuo Inoshima;Masakazu Inagaki;Eigo Sakamoto;Syouzou Sakamoto;Takuma Yanai and Naotaka Ishiguro
• 通讯作者: Takuma Yanai and Naotaka Ishiguro