Pathological study of AA amyloidosis in vaccinated white hens and

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Outbreaks of systemic amyloidosis in flocks of layers are known to be induced by repeated inflammatory stimulation with multiple vaccinations with oil-emulsified bacterins. Outbreaks of fatal AA amyloidosis were observed in vaccinated growing chickens in a large scale poultry farm. Amyloid deposits were observed in postmolten examination of dead hens, suggesting that vaccinations with Salmonella Enteritidis (SE) would be considered as a potential risk for the development of AA amyloidosis. To determine the transmission of chicken AA amyloidosis among white hens, we induced experimental AA amyloidosis in vaccinated chickens by intravenous or oral administration of chicken AA fibrils. Amyloid deposits were observed in chickens ingected with SE and inouculated with chicken AA fibrils intravenously and orally. These results suggest that chicken AA amyloidosis can be induced by vaccinations, and may be transmitted among species.