Study on pathogenesis and transmission of animal AA amyloidosisandtheir enhancing factors

淀粉样蛋白A（Amyloid A，AA）是由高浓度的前体血清淀粉样蛋白A（precursor serum amyloid protein A，SAA）诱导的动物淀粉样变性，其特征是AA蛋白在不同器官和组织中的细胞外沉积。AA淀粉样变性主要见于奶牛和家禽。本研究对AA淀粉样变性病牛和鸡的几种组织进行了组织学检查，并利用鸡和兔模型分析了AA淀粉样变性病的传播机制。根据淀粉样物质沉积和临床症状将牛AA淀粉样变性分为典型淀粉样变性I型和非典型淀粉样变性II型。牛AA淀粉样蛋白在家兔中发生实验性AA淀粉样变性。我们在接种疫苗的白色母鸡中观察到AA淀粉样变性的致死性爆发。鸡AA淀粉样变性病在接种疫苗和鸡淀粉样蛋白的同一种属内传播。

Amyloid A (AA) amyloidosis is induced in animals with high plasma concentration of precursor serum amyloid protein A (SAA), and characterized by the extracellular deposition of AA proteins in different organs and tissues. AA amyloidosis is observed by mainly in cows and table birds. In this study,several tissues from AA amyloidosis affected cows and chickens were histologically examined, and the transmission mechanism of AA amyloidosis was analyzed using chicken and rabbit models. Bovine AA amyloidosis was classified by two types Class I of typical and Class II of atypical amyloidosis by amyloid deposition and clinical symptoms. BovineAA amyloid developed experimental AA amyloidosis in rabbits. We observed fatal outbreaks of AA amyloidosis in white hens inoculated by vaccine. Chicken AA amyloidosis was shown to be transmitted within same species inoculated with vaccine and chicken amyloid.