Study on pathogenesis and transmission of animal AA amyloidosisandtheir enhancing factors

淀粉样蛋白A(Amyloid A，AA)是在血浆前体血清淀粉样蛋白A(SAA)浓度较高的动物体内诱发的淀粉样变性，其特征是不同器官和组织中AA蛋白的胞外沉积。AA淀粉样变性主要见于奶牛和食用禽类。本研究对AA淀粉样变性影响奶牛和鸡的几种组织进行了组织学检查，并利用鸡和兔模型分析了AA淀粉样变性的传播机制。根据淀粉样蛋白沉积和临床症状，将牛AA淀粉样变性分为典型的I型和非典型的II类淀粉样变性。牛AA淀粉样蛋白在兔实验性AA淀粉样变性中发生。我们观察到接种疫苗的白色母鸡中发生了致死性的AA淀粉样变性暴发。鸡AA淀粉样变性在接种疫苗和鸡淀粉样蛋白的同一物种内传播。

Amyloid A (AA) amyloidosis is induced in animals with high plasma concentration of precursor serum amyloid protein A (SAA), and characterized by the extracellular deposition of AA proteins in different organs and tissues. AA amyloidosis is observed by mainly in cows and table birds. In this study,several tissues from AA amyloidosis affected cows and chickens were histologically examined, and the transmission mechanism of AA amyloidosis was analyzed using chicken and rabbit models. Bovine AA amyloidosis was classified by two types Class I of typical and Class II of atypical amyloidosis by amyloid deposition and clinical symptoms. BovineAA amyloid developed experimental AA amyloidosis in rabbits. We observed fatal outbreaks of AA amyloidosis in white hens inoculated by vaccine. Chicken AA amyloidosis was shown to be transmitted within same species inoculated with vaccine and chicken amyloid.