Study on pathogenesis and transmission of animal AA amyloidosisandtheir enhancing factors

动物AA型淀粉样变的发病机制、传播途径及其促进因素的研究

• 批准号: 22380165
• 负责人: ISHIGURO Naotaka
• 金额: $ 12.56万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22380165/
• 关键词: 疾病予防; 制御; ウシ; ニワトリ; ウサギ; アミロイド; 伝播; 伝播性; アイソフォーム; 伝達性; モノクローナル抗体; 血清アミロイドA蛋白質

Amyloid A (AA) amyloidosis is induced in animals with high plasma concentration of precursor serum amyloid protein A (SAA), and characterized by the extracellular deposition of AA proteins in different organs and tissues. AA amyloidosis is observed by mainly in cows and table birds. In this study,several tissues from AA amyloidosis affected cows and chickens were histologically examined, and the transmission mechanism of AA amyloidosis was analyzed using chicken and rabbit models. Bovine AA amyloidosis was classified by two types Class I of typical and Class II of atypical amyloidosis by amyloid deposition and clinical symptoms. BovineAA amyloid developed experimental AA amyloidosis in rabbits. We observed fatal outbreaks of AA amyloidosis in white hens inoculated by vaccine. Chicken AA amyloidosis was shown to be transmitted within same species inoculated with vaccine and chicken amyloid.

淀粉样蛋白A （Amyloid A， AA）淀粉样变性是由血浆中前体血清淀粉样蛋白A （SAA）浓度高引起的，其特征是AA蛋白在不同器官和组织的细胞外沉积。AA淀粉样变主要见于牛和桌鸟。本研究对AA淀粉样变的奶牛和鸡的几种组织进行了组织学检查，并采用鸡和兔模型分析了AA淀粉样变的传播机制。根据淀粉样蛋白沉积及临床症状，将牛AA型淀粉样变性分为典型I型和非典型II型。牛AA淀粉样蛋白在家兔发生实验性AA淀粉样变性。我们观察到接种疫苗的白母鸡发生了致死性AA淀粉样变。鸡AA淀粉样变在接种疫苗和鸡淀粉样蛋白的同一种属内传播。

项目成果

AA amyloidosis in vaccinated growing chickens

接种疫苗的生长鸡中的 AA 淀粉样变性

• DOI: 10.1016/j.jcpa.2013.02.002
• 发表时间: 2013
• 期刊: Journal of Comparative Pathology
• 影响因子: 0.8
• 作者: Murakami T;Inoshima Y;Sakamoto E;Fukushi H;Sakai H;Yanai T;Ishiguro N.
• 通讯作者: Ishiguro N.

牛ＡＡアミロイドーシスにおけるアミロイド沈着パターンの多様性

牛 AA 型淀粉样变性中淀粉样蛋白沉积模式的多样性

• 发表时间: 2011
• 作者: Watanabe S;Ito J;Baba T;Hiratsuka T;Kuse K;Ochi H;Anai Y;Hisasue M;Tsujimoto H;Nishigaki K;村上 智亮
• 通讯作者: 村上 智亮

ニワトリを用いた実験的AAアミロイド-シスの誘発

鸡 AA 淀粉样变性的实验诱导

• 发表时间: 2012
• 作者: 村上智亮;猪島康雄;柳井徳磨;御領政信;石黒直隆
• 通讯作者: 石黒直隆

Atypical AA amyloid deposits in bovine AA amyloidosis

牛 AA 淀粉样变性中的非典型 AA 淀粉样蛋白沉积

• DOI: 10.3109/13506129.2011.637145
• 发表时间: 2012
• 期刊: Amyloid
• 影响因子: 5.5
• 作者: Tomoaki Murakami;Yasuo Inoshima;Yoshiyasu Kobayashi;Takane Matusi;Hisashi Inokuma and Naotaka Ishiguro;後藤康文・高紅梅・小野山一郎・眞鍋昇;Tomoaki Murakami
• 通讯作者: Tomoaki Murakami

Proteasome activity and biological properties of normal prion protein: a comparison between young and aged cattle.

• DOI: 10.1292/jvms.10-0149
• 发表时间: 2010-08
• 期刊: The Journal of veterinary medical science
• 作者: Y. Yoshioka;N. Ishiguro;Y. Inoshima