硫酸角质素在妇科恶性肿瘤中表达的研究-猫眼课题宝

硫酸角质素在妇科恶性肿瘤中表达的研究

批准号：

24659725

负责人：

SHIOZAWA Tanri

金额：

$2.0万

依托单位：

Shinshu University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Challenging Exploratory Research

财政年份：

2012

资助国家：

日本

项目状态：

已结题

起止时间：

2012-04-01 至 2014-03-31

来源：

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659725/

关键词：

ケラタン硫酸婦人科悪性腫瘍子宮内膜症鑑別診断女性生殖管異所性子宮内膜子宮内膜癌卵巣癌診断マーカー

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英文摘要

The immunohistochemical staining using monoclonal antibody for keratan sulfate (KS) revealed that the expression of KS was observed in 96.2% (25/26 cases) of non-neoplastic epithelia in female genital tract including fallopian tube, ovarian inclusion cyst, endocervical gland, eutopic and ectopic endometrium. In contrast, the expression of KS was negligible in digestive organ (1/47 cases, 2.3%) and urinary tract (0/6 cases, 0%). In addition, the expression of KS was observed in 90.6% (29/32 cases) of carcinomas in female genital tract (endometrial, tubal and ovarian carcinoma), whereas observed in 0% (0/33 cases) of other carcinomas in abdominal cavity (digestive tract, liver, kidney and urinary tract). These findings suggest that the immunostaining for KS is useful to discriminate epithelia and carcinomas of female genital tract in abdominal cavity. On the other hand, KS-positive cases were present in breast, lung, thyroid, pancreatic cancer and malignant mesothelioma.

期刊论文(29)

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会议论文

Sirtuin1(SIRT1),a longevity gene,is over-expressed in endometrial carcinoma.

Sirtuin1（SIRT1）是一种长寿基因，在子宫内膜癌中过度表达。

DOI： --

发表时间： 2012

期刊：

影响因子： --

作者：

[Matsumoto K, Hirai Y, Furuta R, Takatsuka N, Oki A, Yasugi T, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H, Asaka R,Miymamoto T,Suzuki A,IshikawaK,Yamada Y,Kobara H,Shiozawa T]

通讯作者： Asaka R,Miymamoto T,Suzuki A,IshikawaK,Yamada Y,Kobara H,Shiozawa T

Identification of novel genes involved in clear cell carcinogenesis of the overy using retrovirus-based cDNA expression library

使用基于逆转录病毒的 cDNA 表达文库鉴定参与透明细胞癌变的新基因

DOI： --

发表时间：

期刊：

影响因子： --

作者：

[Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F., Shiozawa T,Miyamoto T,Suzuki A,Asaka R.]

通讯作者： Shiozawa T,Miyamoto T,Suzuki A,Asaka R.

卵巣明細胞癌発生に関与する新規候補遺伝子の機能的スクリーニング

参与卵巢透明细胞癌发生的新候选基因的功能筛选