A new approach to the different biological function of PTH and PTHrP on osteoblastic cells

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It is well known that intermittent administration of PTH (parathyroid hormone) shows anabolic effects in bone, while continuous injection of PTH results in catabolic effects. When human PTH(1-34) was administered into mice with high frequency, actively-proliferating preosteoblasts, abundant osteoclasts and many mature osteoblasts forming bone matrices were observed, representing high bone turnover. However, when PTH(1-34) was administered with low frequency, preosteoblasts was not so proliferated, with less forming osteoclasts, and mature osteoblasts formed more bone. Meanwhile, the fetuses continuously overexpressing PTHrP (PTH-related peptide) showed a large numbers of preosteoblasts and bone marrow stromal cells without accompanying accelerated osteoclast formation, and a few mature osteoblasts formed bone matrix. Thus, PTH and PTHrP appear to differently show predominant effects to preosteoblastic and osteoblastic activities, despite their binding the common receptor.