Pathogenesis of influenza virus-associated encephalopathy of childhood induced in animal model

动物模型诱导的儿童流感病毒相关性脑病的发病机制

• 批准号: 23658250
• 负责人: UMEMURA Takashi
• 金额: $ 2.5万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23658250/
• 关键词: インフルエンザ性脳症; リポ多糖体; 小児; 血液脳関門; 高サイトカイン血症; インフルエンザ脳症; 感染症; ウイルス; 脳神経疾患; 獣医学; 病理学; 動物

In the present study, I demonstrated that influenza virus (IFV) infection to the lungs of suckling mice enhanced encephalopathy and hypercytokinemia due to lipopolysaccharide (LPS) inoculation, and brain pathology, hypercytokinemia and absence of IFV in the brain of the animal model treated with IFV and LPS were similar to IFV-associated encephalopathy of childhood. Furthermore, it was suggested from the present study that the apoptosis of vascular endothelial cell and astrocytes causing increased permeability of blood brain barrier might be the major contributing factor forIFV-associated encephalopathy of childhood.

在本研究中，我证明了流感病毒(IFV)感染乳鼠肺部可加重脂多糖(LPS)接种所致的脑病和高细胞分裂素血症，而IFV和LPS治疗的动物模型的脑病理、高细胞分裂素血症和IFV缺失症类似于儿童IFV相关性脑病。此外，本研究提示血管内皮细胞和星形胶质细胞的凋亡导致血脑屏障通透性增加可能是儿童IFV相关性脑病的主要致病因素。

项目成果

Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan

• DOI: 10.1099/vir.0.037572-0
• 发表时间: 2012-03-01
• 期刊: JOURNAL OF GENERAL VIROLOGY
• 影响因子: 3.8
• 作者: Sakoda, Yoshihiro;Ito, Hiroshi;Kida, Hiroshi
• 通讯作者: Kida, Hiroshi

CXCL12 improves immune responses to neurotropic virus propagation in the CNS by attracting antigody secreting cells

CXCL12通过吸引抗体分泌细胞来改善中枢神经系统中对嗜神经病毒传播的免疫反应

• 发表时间: 2012
• 期刊: Vet Immunol Microbiol
• 作者: Lee HK;Lee HK;Sunden Y;Sakai Y;Ochiai K;Umemura T
• 通讯作者: Umemura T

Experimental intracerebral vaccination protects mouse from a neurotropic virus by attracting antibody secreting cells to the CNS

• DOI: 10.1016/j.imlet.2011.05.008
• 发表时间: 2011-09-30
• 期刊: IMMUNOLOGY LETTERS
• 影响因子: 4.4
• 作者: Lee, Hyunkyoung;Sunden, Yuji;Umemura, Takashi
• 通讯作者: Umemura, Takashi