Malarial parasite surface proteins: structure and interactions of key merozoite antigens

疟疾寄生虫表面蛋白：关键裂殖子抗原的结构和相互作用

• 批准号: DP0664723
• 负责人: Prof Raymond Norton
• 金额: $ 20.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664723
• 关键词: Malarial; parasite; surface; proteins; structure

Malaria remains one the most lethal infectious diseases in the world today, being directly responsible for around 2 million deaths annually, many in children under 5 years of age. Related parasitic diseases affect livestock in malaria-endemic regions and more broadly. There is an urgent need for an improved understanding of how these parasites invade target red blood cells. Knowing the structures of key proteins on the parasite cell surface will provide a deeper understanding of host-parasite interactions, as well as a basis for the design of vaccines or drugs that interfere with parasite invasion of host red blood cells.

疟疾仍然是当今世界最致命的传染病之一，每年直接造成约200万人死亡，其中许多是5岁以下的儿童。相关的寄生虫病影响疟疾流行地区和更广泛地区的牲畜。迫切需要更好地了解这些寄生虫如何侵入目标红细胞。了解寄生虫细胞表面关键蛋白的结构将提供对宿主-寄生虫相互作用的更深入理解，以及设计干扰寄生虫入侵宿主红细胞的疫苗或药物的基础。