Structure, dynamics and interactions of Plasmodium falciparum merozoite surface protein-2

恶性疟原虫裂殖子表面蛋白2的结构、动力学和相互作用

• 批准号: DP0344826
• 负责人: Prof Raymond Norton
• 金额: $ 20.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-07 至 2005-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0344826
• 关键词: Structure; dynamics; interactions; Plasmodium; falciparum

The solution structure of the merozoite surface protein-2 (MSP-2), from Plasmodium falciparum the causative agent of malaria, will be determined along with an analysis of the motions of residues within the protein. This will allow insights into interactions occurring at the surface coat of the organism, where MSP-2 is a major component. An understanding of how this protein interacts with antibodies of the host's immune system will also be gained. The techniques established during the study of MSP-2 will be useful for the study of larger proteins and protein complexes from many systems in the future.

裂殖子表面蛋白-2（MSP-2），从恶性疟原虫疟疾的病原体，溶液的结构将被确定沿着蛋白质内的残基的运动分析。这将使人们能够深入了解生物体表面涂层处发生的相互作用，其中MSP-2是主要成分。还将了解这种蛋白质如何与宿主免疫系统的抗体相互作用。在MSP-2的研究过程中建立的技术将是有用的，为更大的蛋白质和蛋白质复合物的研究，在未来的许多系统。