Structure-based and fragment-based approaches to developing new therapeutics

基于结构和片段的新疗法开发方法

• 批准号: nhmrc : 1059060
• 负责人: Prof Raymond Norton
• 金额: $ 50.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-based-fragment-new-therapeutics/454727
• 关键词: Structure; based; fragment; approaches; developing

Two powerful and complementary approaches to developing new drugs will be combined to target proteins that play key roles in malaria and other parasite and bacterial infections with the aim of developing new therapeutics. In addition, the potential of peptide toxins to treat autoimmune diseases such as multiple sclerosis, as well as chronic pain and other conditions, will be exploited to develop new drugs.

开发新药的两种强大和互补的方法将结合起来，靶向在疟疾和其他寄生虫和细菌感染中发挥关键作用的蛋白质，以开发新的治疗方法。此外，肽毒素治疗自身免疫性疾病（如多发性硬化症）以及慢性疼痛和其他疾病的潜力将被开发用于开发新药。