Structure and interactions of a disordered malaria surface protein: implications for antigenicity

无序疟疾表面蛋白的结构和相互作用：对抗原性的影响

• 批准号: nhmrc : 637368
• 负责人: Prof Raymond Norton
• 金额: $ 34.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-interactions-disordered-implications-antigenicity/94686
• 关键词: Structure; interactions; disordered; malaria; surface

Malaria is responsible for around 2 million deaths annually, many in children under 5 years of age. Merozoite surface protein 2 (MSP2) from Plasmodium falciparum is being developed as a vaccine candidate. We will investigate the structure of MSP2 in various environments, including when bound to inhibitory antibodies. Key goals are to understand how the disordered structure of MSP2 affects its interaction with the host immune system and how that information can be used to design better vaccines.

疟疾每年造成约200万人死亡，其中许多是5岁以下儿童。恶性疟原虫Merozoite surface protein 2 （MSP2）正被开发为候选疫苗。我们将研究MSP2在各种环境中的结构，包括与抑制性抗体结合时的结构。关键目标是了解MSP2的无序结构如何影响其与宿主免疫系统的相互作用，以及如何利用这些信息来设计更好的疫苗。