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Development of system for determination of odor and taste preference ranking.

开发用于确定气味和味道偏好排名的系统。

基本信息

批准号：
62870006
负责人：
ONO Taketoshi
金额：
$ 2.56万
依托单位：
Department of Physiology, Faculty of Medicine, Totama Medical and Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

Anatomical and physiological studies indicate that the association cortex-amygdala-lateral hypothalamus axis is important-in-recognizing biological significance of external sensory stimuli, such as cue signals predicting food or non-food and the consequent operant responses. However, brain mechanisms in olfactory or gustatory recognition of biologically significant odors and tastes and their associated behavioral responses are not well understood.We have developed two systems for the determination of odor preference ranking and taste preference ranking using microcomputers. these systems consist of an equilateral octagonal cage, a microcomputer, a display, interface of data input and output, a feeder, a light-dark controller, levers or taps on the cage walls, drivers to spray various odor substances or present various tastants with drop sensors, and a deodorization fan. A rat can obtain an odor by pressing the corresponding lever on the wall, or a tastant by licking its tap on the wall … More . A total of eight kinds of odor in one system or tastant in the other can be tested to determine odor preference or taste preference ranking. In this system, all conditions such as lever pressing or drinking signals, input-output relations, light-dark control and recording intervals are under computer control, and data of more than one week, are stored on floppy disks.Using these systems, we analyzed odor and taste preferences of rats in normal, essential amino acid deficient, and food deprived states. Combined with our previously developed operant learning equipment, we clarified changes in responsiveness of hypothalamic neurons under these behaviorally quantified different conditions. These systems are useful for behavioral study of odor and taste preference ranking. and for study, at the single neuron level, of brain mechanisms of olfactory and gustatory recognition of biologically significant odorants and tastants, regulation of internal amino acid correlation with salt or umami appetite, etc. Less

解剖学和生理学研究表明，皮层-杏仁核-下丘脑外侧轴联合体在识别外部感觉刺激的生物学意义，如预测食物或非食物的提示信号以及随后的操作性反应中具有重要作用。然而，在嗅觉或味觉识别的生物学意义上的气味和味道和他们相关的行为反应的大脑机制还没有得到很好的理解。这些系统由正八边形笼、微型计算机、显示器、数据输入和输出接口、进料器、光暗控制器、笼壁上的杠杆或龙头、喷射各种气味物质或呈现具有液滴传感器的各种促味剂的驱动器、以及风扇组成。老鼠可以通过按下墙上相应的杠杆来获得气味，或者通过舔墙上的水龙头来获得促味剂 ...更多信息 .可以测试一个系统中的总共八种气味或另一个系统中的促味剂，以确定气味偏好或味道偏好排名。在该系统中，压杆或饮水信号、输入输出关系、明暗控制和记录间隔等条件均由计算机控制，并将一周以上的数据存储在软盘上，利用该系统分析了正常、必需氨基酸缺乏和食物剥夺状态下大鼠的气味和味觉偏好。结合我们以前开发的操作学习设备，我们阐明了这些行为量化不同条件下丘脑神经元反应性的变化。这些系统是有用的气味和味觉偏好排名的行为研究。以及在单神经元水平上研究嗅觉和味觉识别具有生物学意义的气味和味剂的大脑机制，调节内部氨基酸与盐或鲜味食欲的相关性等。