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Investigation of emotion and mnemonic functions of the primate limbic system by means of invasive and non-invasive methods

通过侵入性和非侵入性方法研究灵长类边缘系统的情感和记忆功能

基本信息

批准号：
06454706
负责人：
ONO Taketoshi
金额：
$ 4.54万
依托单位：
TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454706/
关键词：
Limbic system Primate Neurophysiology Emotion Memory Recognition Dipole tracing fMRI MRI

项目摘要

To elucidate spatial and cognitive function of the septo (SP)-hippocampal (HF) system, neural activity was recorded from alert monkeys during performance of a place-dependent conditional go-nogo task (PCA) task in which response/reinforcement contingencies of given objects were conditional upon the location of a motorized, movable device (cab) containing a monkey, and during the place-independent go-nogo tasks which required no conditional discrimination. Of 329 HF neurons recorded, the activity of 88 increased or decreased significantly in response to the presentation of an object during the PCA task. Responses of 17 neurons depended differentially on specific combinations of object, place and behavior only in the PCA task (specific-combination neurons). Responses of 12 ncurons responded differentially to the objects only in the PCA task (object-differential neurons). Characteristics of the 2 neuron types suggest that HF neurons encode both stimulus percept and attributes such as the … More place where the stimulus is presented, and the conditional relation imposed in the task. These results might be neurophysiological bases of episodic memory, and suggest thet there is linkage between spatial and non-spatial functions in the HF.Of 430 SP neurons recorded, the responses during the place phase in the 4 places were significantly different in 58 neurons. Responses of 8 of these neurons were also place-differential during the object phase as well as the place phase. Of 91 neurons responding differentially during the object phase, 43 responded differentially only in the PCA task, 19 and 2 neurons were related to the reward/nonreward and go/nogo contingencies, respectively. The results suggest that the SP is involved in integrating spatial information, conditional place-object relations, and reward/nonreward contingency.In the non-invasive study, generators of monkey somatosensory evoked potentials (SEPs) in monkeys and visual evoked potentials (VEPs) in humans were investigated by dipole tracing (DT) method with 3-dimensional reconstructed real head model, which can equates surface potential distributions to a corresponding equivalent dipole. The results indicated sequcential movement of dipoles from the thalamus to area 5 via the SI area, and topographic localization of the dipoles around the calcarine fissures which were well comparable to the retinotopy in the occipital lobe. The functional MRI of brains of awake rats during transient whole brain ischemia indicated that the post-ischemic hyperemia which lasts 1 hr was significantly correlated to delayd neuronal death in the CA1 subfield of the HF,and those of a rat brain during licking of glucose solution indicated increase in signal intensity in the hypothalamus. Less

为了阐明隔（SP）-海马（HF）系统的空间和认知功能，记录了警觉猴在执行位置依赖性条件性go-nogo任务（PCA）时的神经活动，在PCA任务中，给定物体的反应/强化偶然性取决于装有猴子的机动可移动装置（驾驶室）的位置，在不需要条件辨别的位置无关的go-nogo任务中也是如此。在记录的329个HF神经元中，88个的活动在PCA任务期间响应于对象的呈现而显著增加或减少。17个神经元的反应仅在PCA任务中（特定组合神经元）依赖于对象，地点和行为的特定组合。12个ncurons的反应差异的对象只在PCA任务（对象差分神经元）。这两种神经元类型的特征表明，HF神经元编码刺激感受和属性，如 ...更多信息刺激呈现的位置，以及任务中施加的条件关系。这些结果可能是情景记忆的神经生理学基础，提示HF的空间和非空间功能之间存在联系。在所记录的430个SP神经元中，有58个SP神经元在位置相的4个位置的反应存在显著差异。这些神经元中的8个的反应在对象阶段以及位置阶段期间也是位置差异的。91个神经元在对象阶段的差异反应，43只在PCA任务的差异反应，19和2个神经元有关的奖励/nonreward和go/nogo应急，分别。在无创性研究中，采用偶极子追踪（DT）方法，利用三维重建的真实的头部模型，研究了猴体感诱发电位（SEP）和人视觉诱发电位（VEP）的发生器，其可以将表面电势分布等同于相应的等效偶极子。结果表明，偶极从丘脑到5区的顺序运动，通过SI区，和地形定位的偶极周围的距状核裂，以及在枕叶视网膜病变的可比性。短暂性全脑缺血时清醒大鼠脑的功能性MRI显示缺血后持续1小时的充血与HF的CA 1区的延迟性神经元死亡显著相关，舔葡萄糖溶液时大鼠脑的功能性MRI显示下丘脑的信号强度增加。少